Browsing by Author "Cai, C."
Now showing items 1-9 of 9
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Can natural fibers be a silver bullet? Antibacterial cellulose fibers through covalent bonding of silver nanotparticles to electrospun fibers
Zheng, Y.; Cai, C.; Zhang, F.; Monty, J.; Linhardt, Robert J.; Simmons, T. (2016)Natural cotton was dissolved in a room-temperature ionic liquid 1-ethyl-3-methyl acetate and wet-jet electrospun to obtain nanoscale cotton fibers with a substantially reduced diameter—and therefore an increased surface ... -
Characteristics of glycosaminoglycans in chicken eggshells and the influence of disaccharide composition on eggshell properties
Liu, Z.; Sun, X.; Cai, C.; He, W.; Zhang, F. (Elsevier, 2016-01-01)Glycosaminoglycans (GAG) are linear, highly negatively charged polysaccharides that may perform an important role in biomineralization. GAG were isolated from chicken eggshell membranes and calcified shells. Disaccharide ... -
Design of homogeneous and reversible low molecular weight heparins
Xu, Y.; Cai, C.; Chandarajoti, K.; Hsieh, P.-H.; Li, L.; Pham, T.Q.; Sparkenbaugh, E.M.; Sheng, J.; Key, N.S.; Pawlinski, R.; Harris, E.N.; Linhardt, Robert J.; Liu, Jian (Nature, 2014)Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. ... -
Green solvents in carbohydrate chemistry: from raw materials to fine chemicals
Farrán, A.; Cai, C.; Sandoval, M.; Xu, Y.; Liu, J.; Hernáiz, M.J.; Linhardt, Robert J. (2015-07-22)In recent decades, there has been an increasing effort to reduce the use of fossil fuels and oil derivatives, to decrease environmental pollution, and to counteract global warming. The use of biomass as raw material is ... -
Heparin stability by determining unsubstituted amino groups using HILIC-MS
Fu, L.; Li, L.; Cai, C.; Li, G.; Zhang, F.; Linhardt, Robert J. (Elsevier, 2014)The thermal instability of the anticoagulant heparin is associated, in part, with the solvolytic loss of N-sulfo groups. This study describes a new method to assess the increased content of unsubstituted amino groups present ... -
New functional tools for anti-thrombogenic activity assessment of live surface glycocalyx
Dimitrievska, S.; Weyers, A.; Lin, T.; Cai, C.; Wu, W.; Tuggle, C.T.; Sundaram, S.; Balestrini, J.L.; Slattery, D.; Tchouta, L.; Kyriakides, T.R.; Tarbell, J.M.; Linhardt, Robert J.; Niklason, L.E. (American Heart Association (AHA) Journals and Wiley, 2016)Objective: It is widely accepted that the presence of a glycosaminoglycan-rich glycocalyx is essential for endothelialized vasculature health; in fact, a damaged or impaired glycocalyx has been demonstrated in many vascular ... -
Stereoselective Total Synthesis of (-)-Cleistenolide
Cai, C.; Liu, J.; Du, Y.; Linhardt, Robert J. (American Chemical Society (ACS), 2010)A facile stereoselective total synthesis of cleistenolide (1) from the natural chiral template d-arabinose has been achieved in eight steps and 49% overall yield, employing key steps including Wittig olefination, selective ... -
Structural characterization and interaction with RCA120 of a highly sulfated keratan sulfate from blue shark (Prionace glauca) cartilage
Li, Q.; Li, G.; Zhao, X.; Shan, X.; Cai, C.; Zhao, J.; Zhang, F.; Linhardt, Robert J.; Yu, G. (Multidisciplinary Digital Publishing Institute (MDPI), 2018)As an important glycosaminoglycan, keratan sulfate (KS) mainly exists in corneal and cartilage, possessing various biological activities. In this study, we purified KS from blue shark (Prionace glauca) cartilage and prepared ... -
Surface modification of a polyethylene film for anticoagulant and anti-microbial catheter
Zheng, Y.; Miao, J.; Zhang, F.; Cai, C.; Koh, A.; Simmons, T.J.; Mousa, S.A.; Linhardt, Robert J. (Elsevier, 2016)A functional anticoagulant and anti-bacterial coating for polyethylene (PE) films is described. The stepwise preparation of this nanocomposite surface coating involves O2 plasma etching of PE film, carbodiimide coupling ...