Browsing by Author "Ibrahimi, O.A."
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A Kinetic Model for FGF, FGFR and Proteoglycan Signal Transduction Complex Assembly
Ibrahimi, O.A.; Zhang, F.; Lang Hrstka, S.C.; Mohammadi, M.; Linhardt, Robert J. (2004)The current working model for fibroblast growth factor receptor (FGFR) dimerization and activation requires the assembly of a ternary complex of fibroblast growth factor (FGF), FGFR, and heparin or heparan sulfate proteoglycan ... -
Analysis of the Biochemical Mechanisms for the Endocrine Actions of FGF23
Yu, X.; Ibrahimi, O.A.; Zhang, F.; Davis, S.I.; Garringer, H.J.; Linhardt, Robert J.; Ornitz, D.M.; Mohammadi, M.; White, K.E. (Oxford, 2005)Fibroblast growth factor (FGF)-23 has emerged as an endocrine regulator of phosphate and of vitamin D metabolism. It is produced in bone and, unlike other FGFs, circulates in the bloodstream to ultimately regulate phosphate ... -
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities in human skeletal disorders
Ibrahimi, O.A.; Zhang, F.; Eliseenkova, A.V.; Itoh, N.; Linhardt, Robert J.; Mohammadi, M. (Oxford, 2004)Gain-of-function missense mutations in FGF receptor 2 (FGFR2) are responsible for a variety of craniosynostosis syndromes including Apert syndrome (AS), Pfeiffer syndrome (PS) and Crouzon syndrome (CS). Unlike the majority ... -
Insights Into the Molecular Basis for FGF Receptor Autoinhibition and Ligand Binding Promiscuity
Olsen, S.K.; Ibrahimi, O.A.; Raucci, A.; Zhang, F.; Eliseenkova, A.V.; Yayon, A.; Basilico, C.; Linhardt, Robert J.; Schlessinger, J.; Mohammadi, M. (2004)The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1-D3) of which the two membrane-proximal D2 and D3 domains and the interconnecting D2-D3 linker bear the ... -
Proline to Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis Syndromes Through the Enhancement of FGF Binding Affinity
Ibrahimi, O.A.; Zhang, F.; Eliseenkova, A.V.; Linhardt, Robert J.; Mohammadi, M. (2004)Identical proline-->arginine gain-of-function mutations in fibroblast growth factor receptor (FGFR) 1 (Pro252Arg), FGFR2 (Pro253Arg) and FGFR3 (Pro250Arg), result in type I Pfeiffer, Apert and Muenke craniosynostosis ...