Browsing by Author "Ibrahimi, Omar A."

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Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

Schlessinger, Joseph; Plotnikov, Alexander N.; Ibrahimi, Omar A.; Eliseenkova, Anna V.; Yeh, Brian K.; Yayon, Avner; Linhardt, Robert J.; Mohammadi, Moosa (2000-01-01)

The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and FGFR, thereby augmenting ...
Structural Basis by which Alternative Splicing Modulates the Organizer Activity of FGF8 in the Brain

Olsen, Shaun K.; Li, James Y.H.; Bromleigh, Carrie; Eliseenkova, Anna V.; Ibrahimi, Omar A.; Lao, Zhimin; Zhang, Fuming; Linhardt, Robert J.; Joyner, Alexandra L.; Mohammadi, Moosa (2006-01-15)

Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-hindbrain region during development. Although the only difference between these isoforms is the presence of an additional 11 amino acids ...