Browsing by Author "Qiao, Meng"
Now showing items 1-5 of 5
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Chemical, enzymatic and biological synthesis of hyaluronic acids
Li, Jingmin; Qiao, Meng; Ji, Yuan; Lin, Lei; Zhang, Xing; Linhardt, Robert J. (2020-06-01)Hyaluronic acid (HA) is a major glycosaminoglycan, a family of structurally complex, linear, anionic hetero-co-polysaccharides. HA is important in various anatomical structures including the eyes, joints, heart and myriad ... -
Recent advances in biotechnology for heparin and heparan sulfate analysis
Qiao, Meng; Lin, Lei; Xia, Ke; Lid, Jun; Zhang, Xing; Linhardt, Robert J. (Elsevier, 2020-11-01)Heparan sulfate (HS) is a class of linear, sulfated, anionic polysaccharides, called glycosaminoglycans (GAGs), which present on the mammalian cell surfaces and extracellular matrix. HS GAGs display a wide range of critical ... -
Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides
Xu, Han; Shen, Baoxing; Qiao, Meng; Linhardt, Robert J.; Zhang, Xing (2021-04-15)Glycans and glycoconjugates in nature include macromolecules with important biological activities and widely distributed in all living organisms. These oligosaccharides and polysaccharides play important roles in a variety ... -
Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development
Lin, Lei; Qiao, Meng; Zhang, Xing; Linhardt, Robert J. (2020-02-15)Carbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important biological roles, involving cell-cell recognition, ... -
Synthesis of selected unnatural sugar nucleotides for biotechnological applications
Qiao, Meng; Li, Bingzhi; Ji, Yuan; Lin, Lei; Linhardt, Robert; Zhang, Xing (Taylor and Francis, 2021-01-01)Sugar nucleotides are the principal building blocks for the synthesis of most complex carbohydrates and are crucial intermediates in carbohydrate metabolism. Uridine diphosphate (UDP) monosaccharides are among the most ...