Now showing items 1-3 of 3

    • A mutant cell library for systematic analysis of heparan sulfate 

      Qiu, Hong; Shi, Songshan; Yue, Jingwen; Xin, Meng; Nairn, Alison V.; Lin, Lei; Liu, Xinyue; Li, Guoyun; Archer-Hartmann, Stephanie A.; Dela Rosa, Mitche; Galizzi, Melina; Wang, Shunchun; Zhang, Fuming; Azadi, Parastoo; van Kuppevelt, Toin H.; Cardoso, Wellington V.; Kimata, Koji; Ai, Xingbin; Moremen, Kelley W.; Esko, Jeffrey D.; Linhardt, Robert J.; Wang, Lianchun (Nature, 2018-11-01)
      Heparan sulfate (HS) is a complex linear polysaccharide that modulates a wide range of biological functions. Elucidating the structure–function relationship of HS has been challenging. Here we report the generation of an ...
    • The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells 

      Mitra, Dipanwita; Hasan, Mohammad H.; Bates, John T.; Bierdeman, Michael A.; Ederer, Dallas R.; Parmar, Rinkuben C.; Fassero, Lauren A.; Liang, Quntao; Qiu, Hong; Tiwari, Vaibhav; Zhang, Fuming; Linhardt, Robert J.; Sharp, Joshua S.; Wang, Lianchun; Tandon, Ritesh (Public Library of Science (PLoS), 2021-08-01)
      Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host ...
    • Heparan sulfate facilitates spike protein-mediated SARS-Cov-2 host cell invasion and contributes to increased infection of SARS-Cov-2 G614 mutant and in lung cancer 

      Yue, Jingwen; Jin, Weihua; Yang, Hua; Faulkner, John; Song, Xuehong; Qiu, Hong; Teng, Michael; Azadi, Parastoo; Zhang, Fuming; Linhardt, Robert J.; Wang, Lianchun (Multidisciplinary Digital Publishing Institute (MDPI), 2021-06-11)
      The severe acute respiratory syndrome (SARS)-like coronavirus disease (COVID-19) is caused by SARS-CoV-2 and has been a serious threat to global public health with limited treatment. Cellular heparan sulfate (HS) has been ...