NMR studies of the chiral and chemical interactions of self-assembled guanosine monophosphate
Authors
Gupta, Akshar P.
ORCID
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Other Contributors
McGown, Linda Baine
Breneman, Curt M.
Kempf, James G.
Ryu, Chang Yeol
Wang, Chunyu
Breneman, Curt M.
Kempf, James G.
Ryu, Chang Yeol
Wang, Chunyu
Issue Date
2013-12
Keywords
Chemistry
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
This dissertation explores the chiral selectivity exhibited by GMP assemblies, and their interactions in nucleotide mixtures. Previous work in the McGown group demonstrated that GMP can separate enantiomers using capillary electrophoresis (CE). However, the quality of chiral selection was dependent on the extended structure of each solute, for example, easily resolving enantiomers of tryptophan, but not amino acids with analogous, but truncated aromatic side chains (phenylalanine and tyrosine). Thus, investigated here are the structural features of GMP assemblies and their interactions with chiral compounds to reveal the basis for enantioselectivity. Solution-state 1H nuclear magnetic resonance (NMR) was used to map site-specific changes in the chemical shifts within both GMP and the chiral solutes.
Description
December 2013
School of Science
School of Science
Department
Dept. of Chemistry and Chemical Biology
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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