Author
Sterner, Eric Russell
Other Contributors
Dordick, Jonathan S.; Linhardt, Robert J.; Tessier, Peter M.; Karande, Pankaj; Gilbert, Ryan;
Date Issued
2014-05
Subject
Chemical and biological engineering
Degree
PhD;
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
Abstract
Additionally, due to the tremendous number of physiological pathways with which heparan sulfates are implicated, a comprehensive study of the critical structure and chemical compositions required for binding and activation remains partially studied. Detailed studies on how GAGs with various structures influence growth factor binding and signal transduction initiation have been extensively studied using a combinatorial approach involving cell-based microarrays.; Glycosaminoglycans (GAGs) represent a division of carbohydrate chemistry with research applications in a variety of engineering, analytical, and biological disciplines. Heparan sulfate, and the structurally related GAG heparin, have been identified as the most important GAGs due to their biological and pharmacological potential. The issues associated with heparan sulfate and heparin research and production are important for the generation of industrial, medical, and academic targets.; Heparin is a therapeutic that can no longer be reliably produced from an animal source. Fluctuations in available animal resources, variability in manufactured animal products, and gaps in current good manufacturing processes add substantial economic burden to the consumer. The potential of heparin as a bioengineered therapeutic will drive the global supply of the pharmaceutical, ensuring the manufacturing safety and relieving patient costs.;
Description
May 2014; School of Engineering
Department
Dept. of Chemical and Biological Engineering;
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection;
Access
Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;