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    Bioengineering heparin : advanced enzymatic, analytical, and biological techniques

    Author
    Sterner, Eric Russell
    View/Open
    172740_Sterner_rpi_0185E_10294.pdf (7.114Mb)
    Other Contributors
    Dordick, Jonathan S.; Linhardt, Robert J.; Tessier, Peter M.; Karande, Pankaj; Gilbert, Ryan;
    Date Issued
    2014-05
    Subject
    Chemical and biological engineering
    Degree
    PhD;
    Terms of Use
    This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/1132
    Abstract
    Additionally, due to the tremendous number of physiological pathways with which heparan sulfates are implicated, a comprehensive study of the critical structure and chemical compositions required for binding and activation remains partially studied. Detailed studies on how GAGs with various structures influence growth factor binding and signal transduction initiation have been extensively studied using a combinatorial approach involving cell-based microarrays.; Glycosaminoglycans (GAGs) represent a division of carbohydrate chemistry with research applications in a variety of engineering, analytical, and biological disciplines. Heparan sulfate, and the structurally related GAG heparin, have been identified as the most important GAGs due to their biological and pharmacological potential. The issues associated with heparan sulfate and heparin research and production are important for the generation of industrial, medical, and academic targets.; Heparin is a therapeutic that can no longer be reliably produced from an animal source. Fluctuations in available animal resources, variability in manufactured animal products, and gaps in current good manufacturing processes add substantial economic burden to the consumer. The potential of heparin as a bioengineered therapeutic will drive the global supply of the pharmaceutical, ensuring the manufacturing safety and relieving patient costs.;
    Description
    May 2014; School of Engineering
    Department
    Dept. of Chemical and Biological Engineering;
    Publisher
    Rensselaer Polytechnic Institute, Troy, NY
    Relationships
    Rensselaer Theses and Dissertations Online Collection;
    Access
    Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;
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