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    Effects of electrospun fiber diameter on astrocyte morphology and reactivity

    Author
    Desmond, Gregory
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    175922_Desmond_rpi_0185N_10604.pdf (622.7Kb)
    Other Contributors
    Gilbert, Ryan; Dai, Guohao; Hahn, Mariah;
    Date Issued
    2015-05
    Subject
    Biomedical engineering
    Degree
    MS;
    Terms of Use
    This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
    Metadata
    Show full item record
    URI
    https://hdl.handle.net/20.500.13015/1450
    Abstract
    A variety of bioengineered scaffolds have previously been fabricated and tested for CNS regeneration following injury. Recent study has examined the effect of these scaffolds on the behavior of astrocytes, demonstrating a link between material topography and astrocyte physiology. In the present study, electrospun fiber scaffolds were fabricated with varying topographical characteristics. Astrocytes were cultured onto these scaffolds in order to examine the effect of fiber diameter and density on cell properties. Fluorescence microscopy showed that scaffolds consisting of larger-diameter, sparser fibers were found to increase aligned elongation and decrease CSPG expression in cultured astrocytes relative to other scaffolds. These results show a clear link between material topography and neuroprotective astrocyte functions. Furthermore, they indicate critical design criteria for repair scaffolds in the post-injury CNS.;
    Description
    May 2015; School of Engineering
    Department
    Dept. of Biomedical Engineering;
    Publisher
    Rensselaer Polytechnic Institute, Troy, NY
    Relationships
    Rensselaer Theses and Dissertations Online Collection;
    Access
    Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;
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