Peptide interactions with crystalline and nanoparticle materials
Authors
Springli, Carl
ORCID
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Other Contributors
Karande, Pankaj
Kane, Ravi S.
Plawsky, Joel L., 1957-
Kane, Ravi S.
Plawsky, Joel L., 1957-
Issue Date
2015-05
Keywords
Chemical engineering
Degree
MS
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
Peptides are a class of molecules which offer a high degree of functional flexibility and simplicity which can be leveraged to develop molecules with high affinity and specificity toward a target. In this work, peptides are investigated for their efficacy in binding to crystalline and nanoparticle inorganic materials. In particular, peptides were screened for the growth inhibition of calcium oxalate monohydrate crystals and the ability to longitudinally link gold nanorods. A robust assay was developed for the high throughput screening of peptides, utilizing Fmoc peptide synthesis, automated image collection, and a machine learning algorithm to analyze images. This assay was used to evaluate the effects of peptide growth modifiers derived from osteocalcin in comparison to calcium oxalate crystal growth without modifiers and also with a known modifier.
Description
May 2015
School of Engineering
School of Engineering
Department
Dept. of Chemical and Biological Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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