Manipulation and separation of objects at the microscale, in solution and at interfaces
Authors
Pandey, Harsh
ORCID
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Other Contributors
Underhill, Patrick T.
Garde, Shekhar
Plawsky, Joel L., 1957-
Ryu, Chang Yeol
Garde, Shekhar
Plawsky, Joel L., 1957-
Ryu, Chang Yeol
Issue Date
2015-08
Keywords
Chemical and biological engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
Many separation techniques rely on different physical or chemical characteristics of the objects being separated. This includes separations based on size, total charge, or strength of interaction with a substrate. Recently there are many contexts in which it is important to manipulate or separate objects with much more subtle differences. For example, there has been significant interest in separating cells with different deformabilities because disease states can lead to changes in flexibility or stiffness, as observed in the red blood cells in sickle cell anemia. Proteins are another example in which manipulating molecules based on their flexibility or deformability (e.g. due to unfolding or di-sulfide bonds) is currently challenging. Further, genomic-length DNA separation and manipulation has direct applications in the development of novel DNA mapping and sequencing devices.
Description
August 2015
School of Engineering
School of Engineering
Department
Dept. of Chemical and Biological Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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