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    Compartmentalization of metabolic pathways into peroxisomes of Saccharomyces cerevisiae

    Author
    Toparlak, Omer Duhan
    View/Open
    176841_Toparlak_rpi_0185N_10696.pdf (8.478Mb)
    Other Contributors
    Koffas, Mattheos A. G.; Linhardt, Robert J.; Kane, Ravi S.; Maxwell, Patrick H.;
    Date Issued
    2015-08
    Subject
    Chemical engineering
    Degree
    MS;
    Terms of Use
    This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/1568
    Abstract
    In the last decade, metabolic engineering benefited greatly from systems and synthetic biology due to substantial advancements in those fields. As a result, technologies and methods evolved to be more complex and controllable than ever. In this thesis, we aimed to improve existing genome engineering technologies to develop controllable and predictable metabolic pathway optimization tool in Saccharomyces cerevisiae. Moreover, we applied up-to-date metabolic engineering pathway balancing techniques to produce drop-in gasoline-replica hydrocarbon biofuels as long-chain alkanes from biological waste, by targeting pathway enzymes into peroxisomes. Lastly, we aimed to engineer the central carbon metabolism of Saccharomyces cerevisiae to develop an acetyl-CoA overproducing strain from biological waste for the production of variety of high-value chemicals and biofuels originated and derived from acetyl-CoA.;
    Description
    August 2015; School of Engineering
    Department
    Dept. of Chemical and Biological Engineering;
    Publisher
    Rensselaer Polytechnic Institute, Troy, NY
    Relationships
    Rensselaer Theses and Dissertations Online Collection;
    Access
    Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;
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    • RPI Theses Online (Complete)

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