[[The]] characterization of flow-induced protein crystallization at the air/water interface
Authors
Young, James E.
ORCID
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Other Contributors
Hirsa, Amir H.
Collins, Cynthia H.
Oberai, Assad
Sahni, Onkar
Tessier, Peter M.
Collins, Cynthia H.
Oberai, Assad
Sahni, Onkar
Tessier, Peter M.
Issue Date
2013-08
Keywords
Mechanical engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
In practice, two-dimensional protein crystallization has been done in quiescent systems with various degrees of success. Recently, it was shown that a bulk flow can enhance two-dimensional protein crystallization by inducing crystallization at a surface pressure where the protein cannot crystallize in a quiescent system. In the present research, the fundamental physics for flow-induced crystallization is examined. This study involves the use of the deep-channel surface viscometer, which consists of an annular flow regime bound by stationary inner and outer cylinders and is driven by a constant rotation of the floor. This geometry allows for the direct measurement of the surface shear viscosity as an indication of the meso-scale interactions that occur during the crystallization process. The results of this study indicate that interfacial strain rate is responsible for flow-induced protein crystallization in two dimensions, similar to flow-induced crystallization in polymer melts in three dimensions.
Description
August 2013
School of Engineering
School of Engineering
Department
Dept. of Mechanical, Aerospace, and Nuclear Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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