Molecular determinants of the thermal expansivity of proteins and volumetric changes upon protein denaturation

Authors
Pandharipande, Pranav
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Other Contributors
Makhatadze, George I.
Cramer, Steven M.
Karande, Pankaj
Plawsky, Joel L., 1957-
Issue Date
2016-05
Keywords
Chemical and biological engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
In this thesis document, I have extensively discussed a variety of molecular determinants of native state expansivity, established how the thermal expansivity obtained using PPC can be used as a probe to study protein compaction, characterized the volumetric properties of the secondary structural elements such as α-helix and β- sheet using PPC, probed the molecular determinants of the change in volume upon protein unfolding (ΔVvoid and ΔVhydration) and finally, shed light on the protein volume paradox resolution and its biological implications for life at extreme environmental conditions.
Description
May 2016
School of Engineering
Department
Dept. of Chemical and Biological Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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