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    Mechanically tunable pullulan-chitin nanocrystal scaffolds for biological applications

    Author
    Sago, Cory
    View/Open
    177585_Sago_rpi_0185N_10923.pdf (8.584Mb)
    Other Contributors
    Gross, Richard; Colón, Wilfredo; McGown, Linda Baine;
    Date Issued
    2016-08
    Subject
    Chemistry and chemical biology
    Degree
    MS;
    Terms of Use
    This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
    Metadata
    Show full item record
    URI
    https://hdl.handle.net/20.500.13015/1786
    Abstract
    The prepared pullulan-ChNC nanocomposite scaffolds offer a unique pathway towards controlling scaffold mechanical properties, morphology, and water retention while dis- playing promise for continued use for in vitro biological studies.; As disease modeling, tissue engineering, and lab on a chip systems advance, it is impera- tive that new scaffolding systems are developed to establish long term models. These scaffolds must be biocompatible, facilitate cell adhesion and mimic the mechanical prop- erties of native tissue.; We report a mechanically tunable scaffold made from pullulan covalently crosslinked by sodium trimetaphosphate. Chitin nanocrystals (ChNC) were added to the hydrogel in var- ious loading percentages. The viscoelastic properties of the crosslinked hydrogel nanocomposites were determined by linear rheology through frequency sweeps. The morphology of the freeze dried nanocomposite scaffolds were characterized by scanning electron microscopy. The rehydration abilities of the scaffolds were also characterized and found to be dependent on the ChNC concentration. The neutral scaffolds do not in- hibit mammalian cell growth, but do not facilitate cell adhesion. The use of the cationic polymer, chitosan, for improved cell adhesion and biocompatibility is explored.;
    Description
    August 2016; School of Science
    Department
    Dept. of Chemistry and Chemical Biology;
    Publisher
    Rensselaer Polytechnic Institute, Troy, NY
    Relationships
    Rensselaer Theses and Dissertations Online Collection;
    Access
    Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;
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