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dc.rights.licenseRestricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.
dc.contributorGross, Richard
dc.contributorColón, Wilfredo
dc.contributorMcGown, Linda Baine
dc.contributor.authorSago, Cory
dc.date.accessioned2021-11-03T08:41:02Z
dc.date.available2021-11-03T08:41:02Z
dc.date.created2016-10-07T11:25:32Z
dc.date.issued2016-08
dc.identifier.urihttps://hdl.handle.net/20.500.13015/1786
dc.descriptionAugust 2016
dc.descriptionSchool of Science
dc.description.abstractThe prepared pullulan-ChNC nanocomposite scaffolds offer a unique pathway towards controlling scaffold mechanical properties, morphology, and water retention while dis- playing promise for continued use for in vitro biological studies.
dc.description.abstractAs disease modeling, tissue engineering, and lab on a chip systems advance, it is impera- tive that new scaffolding systems are developed to establish long term models. These scaffolds must be biocompatible, facilitate cell adhesion and mimic the mechanical prop- erties of native tissue.
dc.description.abstractWe report a mechanically tunable scaffold made from pullulan covalently crosslinked by sodium trimetaphosphate. Chitin nanocrystals (ChNC) were added to the hydrogel in var- ious loading percentages. The viscoelastic properties of the crosslinked hydrogel nanocomposites were determined by linear rheology through frequency sweeps. The morphology of the freeze dried nanocomposite scaffolds were characterized by scanning electron microscopy. The rehydration abilities of the scaffolds were also characterized and found to be dependent on the ChNC concentration. The neutral scaffolds do not in- hibit mammalian cell growth, but do not facilitate cell adhesion. The use of the cationic polymer, chitosan, for improved cell adhesion and biocompatibility is explored.
dc.language.isoENG
dc.publisherRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofRensselaer Theses and Dissertations Online Collection
dc.subjectChemistry and chemical biology
dc.titleMechanically tunable pullulan-chitin nanocrystal scaffolds for biological applications
dc.typeElectronic thesis
dc.typeThesis
dc.digitool.pid177583
dc.digitool.pid177585
dc.digitool.pid177588
dc.rights.holderThis electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
dc.description.degreeMS
dc.relation.departmentDept. of Chemistry and Chemical Biology


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