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    Layer-by-layer laser direct-write 3D-bioprinting for applications in regenerative medicine

    Author
    Tricomi, Brad John
    View/Open
    178193_Tricomi_rpi_0185N_11055.pdf (4.354Mb)
    Other Contributors
    Corr, David T.; Hahn, Juergen; Gilbert, Ryan;
    Date Issued
    2017-05
    Subject
    Biomedical engineering
    Degree
    MS;
    Terms of Use
    This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
    Metadata
    Show full item record
    URI
    https://hdl.handle.net/20.500.13015/1947
    Abstract
    Major advances in regenerative medicine and tissue engineering are currently limited by the inability to accurately recreate the in vivo microenvironment, grow cells or tissues in 3D, properly maintain and control stem cell fate, and fabricate scaffolds that provide adequate mechanical properties for 3D cellular growth, attachment, and mechanotransduction. Three-dimensional (3D) bioprinting is a promising fabrication technique to address each of these limitations. Specifically, gelatin-based laser direct-write (LDW) 3D bioprinting has the potential to fabricate multiple, thick, heterogeneous cellular constructs in a layer-by-layer fashion. Herein, further characterization of the influence of print height and density for the LDW bioprinting process is firstly evaluated. Then, the demonstration of the capacity for LDW to biofabricate multiple, thick, multilayer cellular constructs and then 3D-recronstructions using Mesoscopic Fluorescence Molecular Tomography (MFMT), is investigated. Finally, future directions for the capability of this bioprinting platform to possibly recreate multilayer, histology-grade constructs from micrographs of histologic specimens, is discussed. Taken together, this LDW-MFMT platform may provide a powerful tool for applications in tissue engineering, regenerative, diagnostic, and therapeutic medicine;
    Description
    May 2017; School of Engineering
    Department
    Dept. of Biomedical Engineering;
    Publisher
    Rensselaer Polytechnic Institute, Troy, NY
    Relationships
    Rensselaer Theses and Dissertations Online Collection;
    Access
    Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;
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    • RPI Theses Online (Complete)

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