Show simple item record

dc.rights.licenseRestricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.
dc.contributorCorr, David T.
dc.contributorHahn, Juergen
dc.contributorGilbert, Ryan
dc.contributor.authorTricomi, Brad John
dc.date.accessioned2021-11-03T08:48:28Z
dc.date.available2021-11-03T08:48:28Z
dc.date.created2017-07-03T14:12:52Z
dc.date.issued2017-05
dc.identifier.urihttps://hdl.handle.net/20.500.13015/1947
dc.descriptionMay 2017
dc.descriptionSchool of Engineering
dc.description.abstractMajor advances in regenerative medicine and tissue engineering are currently limited by the inability to accurately recreate the in vivo microenvironment, grow cells or tissues in 3D, properly maintain and control stem cell fate, and fabricate scaffolds that provide adequate mechanical properties for 3D cellular growth, attachment, and mechanotransduction. Three-dimensional (3D) bioprinting is a promising fabrication technique to address each of these limitations. Specifically, gelatin-based laser direct-write (LDW) 3D bioprinting has the potential to fabricate multiple, thick, heterogeneous cellular constructs in a layer-by-layer fashion. Herein, further characterization of the influence of print height and density for the LDW bioprinting process is firstly evaluated. Then, the demonstration of the capacity for LDW to biofabricate multiple, thick, multilayer cellular constructs and then 3D-recronstructions using Mesoscopic Fluorescence Molecular Tomography (MFMT), is investigated. Finally, future directions for the capability of this bioprinting platform to possibly recreate multilayer, histology-grade constructs from micrographs of histologic specimens, is discussed. Taken together, this LDW-MFMT platform may provide a powerful tool for applications in tissue engineering, regenerative, diagnostic, and therapeutic medicine
dc.language.isoENG
dc.publisherRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofRensselaer Theses and Dissertations Online Collection
dc.subjectBiomedical engineering
dc.titleLayer-by-layer laser direct-write 3D-bioprinting for applications in regenerative medicine
dc.typeElectronic thesis
dc.typeThesis
dc.digitool.pid178192
dc.digitool.pid178193
dc.digitool.pid178194
dc.rights.holderThis electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
dc.description.degreeMS
dc.relation.departmentDept. of Biomedical Engineering


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record