Browsing Rensselaer Libraries by Author "Underhill, Patrick T."
Now showing items 1-20 of 48
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A band structure framework for understanding sorption processes : the role of Mn (III) in Cr (III) oxidation
Wang, Chenying (Rensselaer Polytechnic Institute, Troy, NY, 2020-08)In the natural environment, manganese oxide is known for its excellent adsorption properties and strong oxidation ability. The interaction between Cr and Mn oxides is complex, which is not only due to the absorption and ... -
Affinity precipitation of monoclonal antibodies using stimuli responsive smart biopolymers : methods development and process considerations
Sheth, Rahul Dinesh (Rensselaer Polytechnic Institute, Troy, NY, 2014-05)Development of novel protein purification approaches is crucial for sustaining the continued growth of the biopharmaceutical industry. Elastin-like polypeptides (ELPs) are stimuli responsive smart biopolymers which undergo ... -
Atoms and springs : on the development and use of models to study polymer behavior
Setaro, Angelo C. (Rensselaer Polytechnic Institute, Troy, NY, 2020-05)Third, we concern ourselves with the development of a coarse grained model of the worm like chain. Currently, no model exists that can well reproduce the behavior of the worm like chain over the length scale of 0.2-2 ... -
Biophysical and bioinformatics analysis of antibody colloidal and conformational stability
Alam, Magfur E (Rensselaer Polytechnic Institute, Troy, NY, 2019-12)There has been an explosion in the development of therapeutic monoclonal antibodies (mAbs) in recent years due to their high affinities, specificities, stabilities and other drug-like properties. The development of antibody ... -
Breakdown and reliability of nanoscale dielectric films
Ogden, Sean P. (Rensselaer Polytechnic Institute, Troy, NY, 2017-12)The model equations are refined to expand its failure prediction capabilities. The electron temperature is re-defined solely as a function of the electric field, and the defect generation rate is more closely aligned with ... -
Coarse graining solvent polymer interactions in bead spring chain models
Radhakrishnan, Rangarajan (Rensselaer Polytechnic Institute, Troy, NY, 2013-05)Study of dynamics of polymers in dilute solutions is fundamental for solving various problems involving flow behavior of proteins, DNA and synthetic polymers. In a dilute solution, monomers of a single polymer molecule ... -
Colloidal suspensions : from Janus motors to antibody solutions
Tang, Edmund M. (Rensselaer Polytechnic Institute, Troy, NY, 2018-12)From ketchup to toothpaste, colloids are as ubiquitous as they are useful to people’s lives. As technology involving colloids advances, we are finding new and interesting ways to take advantage of colloidal suspensions. ... -
Complex-shaped particle fabrication from inertial microfluidics
Paulsen, Kevin (Rensselaer Polytechnic Institute, Troy, NY, 2017-12)Next, a modification of optofluidic fabrication is introduced to break the top-down symmetry observed in all of the original 3D particle shapes. By introducing the time dimension into our existing optofluidic fabrication ... -
Computational studies of co-solvent effects on protein stability
Canchi, Deepak R. (Rensselaer Polytechnic Institute, Troy, NY, 2011-12) -
Controlled crystallization of small molecule organic compounds using polymers
Kangovi, Gagan N. (Rensselaer Polytechnic Institute, Troy, NY, 2019-05)Crystallization of organic compounds is of great industrial and academic importance. It affects many properties of functional materials such as the dissolution kinetics, self-assembly, purity, and electronic and optical ... -
Deterministic and stochastic modeling of polymerization kinetics with membrane applications
Keating, John J., IV (Rensselaer Polytechnic Institute, Troy, NY, 2020-08)Commercial regenerated cellulose membranes with 1 kDa molecular weight cutoff (MWCO) were grafted with chiral L-proline-copper complexes to form chiral ligand exchange membranes. The resulting membranes were evaluated in ... -
Dielectric breakdown in nano-porous thin films
Borja, Juan Pablo (Rensselaer Polytechnic Institute, Troy, NY, 2014-08)Unknown to most computer users and mobile device enthusiasts, we have finally entered into a critical age of chip manufacturing. January of 2014 marks the official start of the quest by the semiconductor industry to ... -
Drop impact dynamics with sessile drops and geometries : spreading, jetting, and fragmentation
Tilger, Christopher F. (Rensselaer Polytechnic Institute, Troy, NY, 2017-05)The tendency of surface tension to cause small parcels of fluid to form into drops allows convenient packaging, transport, dispersal of liquid phase matter. Liquid drop impacts with solids, liquids, and other drops have ... -
Effect of hydrophobic residues on amyloid formation under steady shear and at interfaces
McBride, Samantha Ann (Rensselaer Polytechnic Institute, Troy, NY, 2015-08)A surprisingly large number of proteins of different shapes, sizes, and functions are capable of undergoing fibrillization transformations in which protein monomers become unstable and begin to combine in a crystalline ... -
Effective properties of random composites and fiber networks
Ban, Ehsan (Rensselaer Polytechnic Institute, Troy, NY, 2015-12)Random fiber networks are assemblies of one-dimensional mechanical elements used to model the mechanics of various natural and man-made materials such as biopolymer gels and synthetic nonwovens. The small-strain mechanics ... -
Elucidating the role of multimodal ligand surfaces in protein chromatography using molecular dynamics simulations
Vats, Mayank (Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Over the past several years, protein-based therapeutics have revolutionized the pharmaceutical industry, with applications for treatment of a range of diseases from autoimmune to cancer. This rise has been accompanied by ... -
Enzyme-catalyzed self-propelling particles : applications for drug delivery to solid tumors
Rao, Suhas (Rensselaer Polytechnic Institute, Troy, NY, 2014-08)We report the design and synthesis of silica Janus motors via the Pickering emulsion method, using a naturally occurring enzyme, catalase, which catalyzes the decomposition of hydrogen peroxide into water and oxygen. Enzymes ... -
Fundamental and applied studies of polymer membranes
Imbrogno, Joseph (Rensselaer Polytechnic Institute, Troy, NY, 2016-05)With the recent increase of feed titer concentrations in the biotechnology industry, the majority of the costs of a given process have been shifted downstream. In order to overcome this problem, we have developed a novel ... -
High-throughput analysis of antibody colloidal stability using nanoparticle-antibody conjugates
Sule, Shantanu (Rensselaer Polytechnic Institute, Troy, NY, 2013-08)In Chapter 2, we have evaluated the ionic-strength dependent self-association of three mAbs using self-interaction chromatography for a range of pH values commonly used in antibody formulation (pH 4-6). We find that antibody ... -
How interfaces affect the behavior of water and water-mediated interactions : molecular theory and simulations
Jamadagni, Sumanth N. (Rensselaer Polytechnic Institute, Troy, NY, 2010-05)