Browsing Rensselaer Libraries by Subject "Chemical engineering"
Now showing items 1-20 of 164
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A band structure framework for understanding sorption processes : the role of Mn (III) in Cr (III) oxidation
(Rensselaer Polytechnic Institute, Troy, NY, 2020-08)In the natural environment, manganese oxide is known for its excellent adsorption properties and strong oxidation ability. The interaction between Cr and Mn oxides is complex, which is not only due to the absorption and ... -
A protein surface properties perspective on multimodal chromatography : from fundamental understanding to predictive tools
(Rensselaer Polytechnic Institute, Troy, NY, 2018-12)The QSAR methodology was extended to predict the retention of homologous Fab variants in multimodal systems for the first time. A new class of descriptors, called local descriptors, was introduced to quantify subtle changes ... -
A study of biomolecules as growth modifiers of calcium oxalate crystals
(Rensselaer Polytechnic Institute, Troy, NY, 2017-05)We investigated calcium oxalate monohydrate (COM), found in plants and kidney stones, as a model system of crystallization. We studied the effects of four common proteins on COM crystallization: bovine serum albumin (BSA), ... -
Advanced functional nanoporous coatings/membranes : preparation by surface or interfacial reactions, characterization, and applications
(Rensselaer Polytechnic Institute, Troy, NY, 2020-08)A novel liquid phase interfacial reaction (LPIR) was developed to fabricate a dense organic-inorganic hybrid coating to cover the pore mouth of mesoporous materials. After thermal treatment, the dense hybrid coating was ... -
Aggregation and binding: a fundamental study of amyloid and antimicrobial peptides
(Rensselaer Polytechnic Institute, Troy, NY, 2016-05)For amyloidogenic peptides, their adverse health effects are primarily derived from their ability to aggregate into small oligomers and subsequently large fibrils. Here, an aggrega-tion reaction model is developed in order ... -
Ambient pressure synthesis and characterization of strongly correlated oxides
(Rensselaer Polytechnic Institute, Troy, NY, 2022-05)Strongly correlated oxides are an important class of materials with a vast array of intriguing optical, electrical, electrochemical, dielectric, and catalytic properties which makes them extremely attractive for a variety ... -
Analysis of natural and synthetic systems for photo-initiated water splitting
(Rensselaer Polytechnic Institute, Troy, NY, 2021-05)The search for new sustainable energy sources has seen a substantial increase inattention as our current reliance on fossil fuels reaches a critical point in terms of supply and environmental impact. One promising avenue ... -
Application of synthetic biology and optogenetics to controlling gene expression
(Rensselaer Polytechnic Institute, Troy, NY, 2014-08)Synthetic biology provides the platform and tools to design artificial regulators to control mRNA translation. In this work, we report a genetically encoded system to regulate mRNA translation using the Pumilio and FBF ... -
Applications for Bacillus megaterium in synthetic biology and modular protein and peptide secretion
(Rensselaer Polytechnic Institute, Troy, NY, 2015-05)The second half of our work describes the development and characterization of a novel system for modular protein/peptide secretion from B. megaterium. Secretion can often lead to increased stability and solubility of ... -
Applications of high throughput screening platforms for biologics discovery
(Rensselaer Polytechnic Institute, Troy, NY, 2021-08)New drug discovery can be a very challenging and complex process due to the length and costs associated with the endeavor. To address this issue, high throughput screening (HTS) platforms have been instrumental in accelerating ... -
Artificial intelligence to improve blood glucose control for people with type 1 diabetes
(Rensselaer Polytechnic Institute, Troy, NY, 2020-12)Automatic activity detections and forecasts can allow a controller to prompt for meals and anticipate exercise. To this end, an automatic activity detection framework using a smartwatch and smartphone has been developed. ... -
Atoms and springs : on the development and use of models to study polymer behavior
(Rensselaer Polytechnic Institute, Troy, NY, 2020-05)Third, we concern ourselves with the development of a coarse grained model of the worm like chain. Currently, no model exists that can well reproduce the behavior of the worm like chain over the length scale of 0.2-2 ... -
Biochemical and physical characterization of C-5 epimerase and 2-O-sulfotransferase
(Rensselaer Polytechnic Institute, Troy, NY, 2015-05)Little is understood regarding the stability of the enzymes and as a result, studies were conducted to elucidate the dynamics of enzymes C-5 epimerase and 2-O-Sulfotransferase. Results are that both C-5 epimerase and ... -
Biochemical and structural characterization of intein inhibitors for use as anti-mycobacterial therapeutics
(Rensselaer Polytechnic Institute, Troy, NY, 2015-12)The human pathogen Mycobacterium tuberculosis harbor inteins, self-splicing protein elements, in critical dnaB, recA and sufB genes. Inteins render the host protein non-functional until splicing occurs, thus inhibition of ... -
Biophysical analysis of monoclonal antibodies using immunogold conjugates
(Rensselaer Polytechnic Institute, Troy, NY, 2016-12)This high-throughput screening assay – which we refer to as affinity-capture self-interaction nanoparticle spectroscopy (AC-SINS) – involves first coating gold particles with capture (anti-mAb) antibodies and then using ... -
Biophysical and bioinformatics analysis of antibody colloidal and conformational stability
(Rensselaer Polytechnic Institute, Troy, NY, 2019-12)There has been an explosion in the development of therapeutic monoclonal antibodies (mAbs) in recent years due to their high affinities, specificities, stabilities and other drug-like properties. The development of antibody ... -
Biophysical investigation for elucidating complex chromatographic behavior in downstream processing of biologics
(Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Monoclonal antibodies (mAbs) have emerged as highly important protein therapeutics in the recent years. In spite of targeting a wide array of targets, mAbs have a conserved amino acid sequence and structure and share a ... -
Biophysical investigation of protein-ligand interactions in multimodal chromatography
(Rensselaer Polytechnic Institute, Troy, NY, 2014-12)The chromatographic resin surfaces were mimicked by the use of self-assembled monolayers (SAMs) functionalized with specific MM ligand chemistries. The binding process of proteins to these fabricated MM surfaces was ... -
BitTorrent-inspired management of residential distributed energy resources
(Rensselaer Polytechnic Institute, Troy, NY, 2015-12)Distributed resources such as solar PV, Li-ion batteries, fuel cell systems, and large flexible loads such as water heaters and HVAC equipment could, if properly managed, provide a significant resource to the grid and ... -
Breakdown and reliability of nanoscale dielectric films
(Rensselaer Polytechnic Institute, Troy, NY, 2017-12)The model equations are refined to expand its failure prediction capabilities. The electron temperature is re-defined solely as a function of the electric field, and the defect generation rate is more closely aligned with ...