Time-resolved hyperspectral compressive single-pixel wide-field optical imaging
Authors
Pian, Qi
ORCID
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Other Contributors
Intes, Xavier
Wang, Ge, 1957-
Hahn, Juergen
Lesage, Frederic
Cuccia, David, 1956-
Wang, Ge, 1957-
Hahn, Juergen
Lesage, Frederic
Cuccia, David, 1956-
Issue Date
2017-08
Keywords
Biomedical engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
The characteristics of Hadamard matrix-based 2D spatial multiplexing on the proposed platform, regarding information content and noise, were analyzed theoretically and validated experimentally. Further, the system performance for hyperspectral 2D spatial multiplexing was validated in lifetime-enhanced molecular imaging. Quantitative investigations of in vitro antibody reactions and in vivo ligand-receptor engagement were demonstrated via sensing of FRET (Förster resonance energy transfer) signals. The quantitative accuracy of the proposed system was benchmarked against a well-established gated intensified CCD-based system and found to be within ±6% absolute margin of the ground truth.
Description
August 2017
School of Engineering
School of Engineering
Department
Dept. of Biomedical Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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