Enhancing protein activity and stability via scaffold engineering
Authors
Basore, Danielle Anna
ORCID
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Other Contributors
Bystroff, Christopher, 1960-
Gilbert, Susan P.
Gross, Richard
Wang, Chunyu
Gilbert, Susan P.
Gross, Richard
Wang, Chunyu
Issue Date
2018-05
Keywords
Biochemistry and biophysics
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
In a similar vein, a chimeric VLP vaccine antigen has been designed to provide universal protection from the dengue virus. 350 million people are infected with this virus every year, and while a vaccine from Sanofi-Pasteur has just been approved, it does not offer complete and universal protection against all serotypes of the virus. We have proposed a construct composed of the fusion loop of the envelope protein of dengue virus, a highly conserved region of the protein known to stimulate a neutralizing antibody response.
Description
May 2018
School of Science
School of Science
Department
Biochemistry and Biophysics Program
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
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