Developing millimeter-scale indentation to probe local cellular environments
Authors
Dass, Rachel Elizabeth
ORCID
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Other Contributors
Mills, Kristen L.
Gilbert, Ryan
Wan, Leo Q.
Hahn, Mariah
Gilbert, Ryan
Wan, Leo Q.
Hahn, Mariah
Issue Date
2018-12
Keywords
Biomedical engineering
Degree
MS
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
It was found that agarose indentation elastic modulus increases with concentration (w/v) and that stress-relaxation properties generally remain constant across concentrations. Solvent-type and aging of agarose over a two week period do not change indentation elastic modulus. In addition, this indentation technique is capable of measuring the mechanical properties of other in vitro models and tissue materials. Fiber-reinforced hydrogels, a novel hybrid fiber-gel in vitro ECM model, were tested as an additional in vitro material. Explant tissue, rat mammary glands, were also measured for comparison with in vitro models. Overall, this milli-scale indentation provides a versatile technique to assess elastic and viscoelastic material properties for improved design and development of in vitro models for a wide range of tissue engineering applications.
Description
December 2018
School of Engineering
School of Engineering
Department
Dept. of Biomedical Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
Access
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