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    Investigation of the effects of nucleotide mutations in the loop regions of the vegf gene promoter g-quadruplex sequence on its protein binding specificity

    Author
    DeWitt, Dylan
    View/Open
    180027_DeWitt_rpi_0185N_11674.pdf (1.356Mb)
    Other Contributors
    McGown, Linda Baine; Lakshmi, K. V.; Linhardt, Robert J.;
    Date Issued
    2020-05
    Subject
    Chemistry
    Degree
    MS;
    Terms of Use
    This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.;
    Metadata
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    URI
    https://hdl.handle.net/20.500.13015/2517
    Abstract
    This project focuses on the investigation of the effects on binding specificity of mutations in the VEGF promoter sequence that was identified to bind to a few nuclear proteins. The VEGF promoter was previously discovered by our group to be a promising potential aptamer using our genome-inspired reverse selection approach to aptamer discovery. The goal of this project was to learn more about the effects of sequence mutations on the binding specificity of the VEGF promoter. These studies demonstrate that nucleotide base mutations in the loop regions of the VEGF promoter can improve its specificity and reveals the potential of future research into the mutation of aptamer sequences.;
    Description
    May 2020; School of Science
    Department
    Dept. of Chemistry and Chemical Biology;
    Publisher
    Rensselaer Polytechnic Institute, Troy, NY
    Relationships
    Rensselaer Theses and Dissertations Online Collection;
    Access
    Restricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.;
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    • RPI Theses Online (Complete)

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