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dc.rights.licenseRestricted to current Rensselaer faculty, staff and students. Access inquiries may be directed to the Rensselaer Libraries.
dc.contributorPalermo, Edmund
dc.contributorOzisik, Rahmi
dc.contributorGilbert, Ryan
dc.contributorUllal, Chaitanya
dc.contributor.authorFalcone, Phillip
dc.date.accessioned2021-11-03T09:17:18Z
dc.date.available2021-11-03T09:17:18Z
dc.date.created2020-08-13T14:01:33Z
dc.date.issued2020-05
dc.identifier.urihttps://hdl.handle.net/20.500.13015/2528
dc.descriptionMay 2020
dc.descriptionSchool of Engineering
dc.description.abstractThe intent of this project is to characterize the properties and the kinetics of release of polyprodrugs made from estradiol and curcumin to develop biomaterials to be used with neuroprotective applications. For both carbonate linked and ester linked varieties of estradiol polyprodrugs of estradiol, the thermal and mechanical properties of hexyl based and oligo(ethylene glycol) (oEG) based polyprodrugs were characterized, as well as the kinetics of prodrug release. It was observed that the presence of oEG/hexyl groups had a more substantial effect on stiffness, hardness, and degradation rate than the type of linkage. It was also observed that for short timescale under human body mimetic conditions, the polyprodrugs of estradiol examined in this study all exhibited similar release kinetics. The chemistry of synthesizing curcumin-co-PEG polyprodrugs was explored, and the thermal and mechanical properties tested. A lack of control of molecular weight lead to lack of predictable property trends across the different curcumin containing polymers that were studied. This project is a continuation of the work on poly(pro-estradiol) materials by D'Amanto et al.
dc.language.isoENG
dc.publisherRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofRensselaer Theses and Dissertations Online Collection
dc.subjectMaterials engineering
dc.titleControlling the properties and degradation kinetics of polyprodrug films
dc.typeElectronic thesis
dc.typeThesis
dc.digitool.pid180062
dc.digitool.pid180063
dc.digitool.pid180076
dc.digitool.pid180064
dc.digitool.pid180065
dc.digitool.pid180066
dc.digitool.pid180067
dc.digitool.pid180068
dc.digitool.pid180069
dc.digitool.pid180070
dc.digitool.pid180071
dc.digitool.pid180072
dc.digitool.pid180073
dc.digitool.pid180074
dc.digitool.pid180075
dc.rights.holderThis electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
dc.description.degreeMS
dc.relation.departmentDept. of Materials Science and Engineering


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