Mechanics- and morphology-mimicking microchannel models of tumor microenvironments
Authors
Kulwatno, Jonathan
ORCID
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Other Contributors
Mills, Kristen L.
Chan, D. D. (Deva D.)
Wan, Leo Q.
Corr, David T.
Chan, D. D. (Deva D.)
Wan, Leo Q.
Corr, David T.
Issue Date
2020-05
Keywords
Biomedical engineering
Degree
PhD
Terms of Use
This electronic version is a licensed copy owned by Rensselaer Polytechnic Institute, Troy, NY. Copyright of original work retained by author.
Full Citation
Abstract
In this thesis, we took into consideration the structure of tubular tissues by considering them cylinders within a matrix, molding microchannels within materials to simulate the structure of these tissues. We then highlighted the importance of tubular tissue geometry in two ways: 1) we studied the influence of a vessel-like constraint on tumor emboli growth and morphology, demonstrating how the mechanical interplay between the emboli and vessel-like geometry can direct its growth and morphology and 2) we developed an organotypic mammary duct model that can recapitulate key features of breast cancer progression that is currently absent from literature.
Description
May 2020
School of Engineering
School of Engineering
Department
Dept. of Biomedical Engineering
Publisher
Rensselaer Polytechnic Institute, Troy, NY
Relationships
Rensselaer Theses and Dissertations Online Collection
Access
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