Browsing RPI Theses Online (Complete) by Author "Hahn, Mariah"
Now showing items 1-20 of 21
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Analysis of intraoperative technique and its effect on loading patterns across the patellofemoral joint using a smart patellar implant
Dion, Matthew Kenneth (Rensselaer Polytechnic Institute, Troy, NY, 2017-12)To better understand the effects of total knee arthroplasty on knee biomechanics, we developed and validated a “smart” patellar implant for measuring forces in the knee. Patellar implants were created by instrumenting ... -
Applications of microengineered platforms to study human laterality disorders
Rico-Varela, Jennifer (Rensselaer Polytechnic Institute, Troy, NY, 2019-12)During the early stages of pregnancy, exposure to certain pharmaceutical drugs can potentially lead to human laterality disorders (HLD). These disorders are characterized by alterations in the shape and positioning of ... -
Cell chirality in three-dimensional epithelial tissue morphogenesis
Chin, Amanda S. (Rensselaer Polytechnic Institute, Troy, NY, 2018-08)To investigate inherent cellular chirality in 3D, we developed a dual layered Matrigel system and studied the role of chirality in morphogenesis and tumor development, as well as its mediating factors. Cultivation of ... -
Characterization of intracortical microelectrode coatings to mitigate scarring and neurodegeneration in vivo
Ziemba, Alexis (Rensselaer Polytechnic Institute, Troy, NY, 2020-05)Pilot studies assessing the compatibility of the coatings revealed the hypothermic coating was toxic while PCPC coating was deemed suitable for future testing. The uniformity was assessed using scanning and confocal ... -
Developing millimeter-scale indentation to probe local cellular environments
Dass, Rachel Elizabeth (Rensselaer Polytechnic Institute, Troy, NY, 2018-12)It was found that agarose indentation elastic modulus increases with concentration (w/v) and that stress-relaxation properties generally remain constant across concentrations. Solvent-type and aging of agarose over a two ... -
Development of bioactive biomaterials for pluripotent stem cell arterial venous differentiation
Dorsey, Taylor Braam (Rensselaer Polytechnic Institute, Troy, NY, 2016-12)Within the framework of this thesis, we proposed to investigate ephrinB2/EphB4 signaling with respect to vascular and arterial venous pluripotent stem cell fate in vitro, specifically utilizing biomaterial approaches to ... -
Direct and indirect endothelial regulation of neural progenitor cells : a modular approach to understand the neural stem cell niche
Dumont, Courtney Margaret (Rensselaer Polytechnic Institute, Troy, NY, 2014-08)The dynamic EC phenotype will produce soluble (cytokines) and insoluble (matrix) fractions that are biochemically distinct from statically produced EC phenotype. NPCs exposed to the dynamic EC-soluble fraction, comprised ... -
Effects of electrospun fiber diameter on astrocyte morphology and reactivity
Desmond, Gregory (Rensselaer Polytechnic Institute, Troy, NY, 2015-05)A variety of bioengineered scaffolds have previously been fabricated and tested for CNS regeneration following injury. Recent study has examined the effect of these scaffolds on the behavior of astrocytes, demonstrating a ... -
Electrospun polyester fiber composites for controlled release of parathyroid hormone
Joshi, Shreel (Rensselaer Polytechnic Institute, Troy, NY, 2012-12) -
Engineered micro and nanotopography for neuron and glial guidance after spinal cord injury
Johnson, Christopher David Landis (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Spinal cord injury presents many barriers to regeneration that have yet to be solved. Guidance conduits are a promising approach that allow regenerating tissue to bypass or traverse the injury site. Peripheral nerve ... -
Enhancing drug delivery from electrospun fiber scaffolds for neural tissue engineering
D'Amato, Anthony R. (Rensselaer Polytechnic Institute, Troy, NY, 2018-12)The final aim in this study details the creation of an entirely new polymer that is made out of E2. With the help of Dr. Palermo’s lab, I synthesized a new, slowly-degrading E2 and polyethylene glycol (PEG) copolymer (PPEAP) ... -
Human endothelial cell response to thromboresistant collagen-mimetic hydrogels
Malmut, Sarah (Rensselaer Polytechnic Institute, Troy, NY, 2014-08)To address these issues, Browning et al. have developed a composite vascular graft composed of an electrospun mesh that acts as a reinforcing outer layer and a non-thrombogenic inner hydrogel-based layer that promotes ... -
Na+ transporters critical for infection and adaptation of Pseudomonas aeruginosa in Drosophila melanogaster
Joseph, Gemel Amillia Georgette (Rensselaer Polytechnic Institute, Troy, NY, 2020-05)We found that the Na+-NQR deletion produced no change in the bacterium’s ability to kill the flies, while the Mrp deletion produced a significantly reduced virulent rate in the bacterium. The reason for altered infectivity ... -
Non-canonical cell stress in osteogenesis imperfecta
Gorrell, Laura (Rensselaer Polytechnic Institute, Troy, NY, 2021-05)We used this model to demonstrate noncanonical quality control of PC1 folding. Like other secretory proteins, PC1 misfolds and accumulates in the lumen of endoplasmic reticulum (ER), disrupting the function of this crucial ... -
Protease-catalyzed synthesis of oligo(l-aspartic acid) and its use for bioadhesives
Yang, Fan (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Poly(aspartic acid) is a biodegradable water-soluble polymer. It has been studied as an alternative to traditional anionic water-soluble polymers such as poly(acrylic acid). It also has potential uses in scaffolding for ... -
Stem cell-based scaffolds for orthopedic applications
Gharat, Tanmay Pradip (Rensselaer Polytechnic Institute, Troy, NY, 2016-08)In the proposed work, we fabricated bioactive scaffolds in combination with stem cells and growth factors. Towards this goal, we made use tunable polyethylene glycol diacrylate (PEGDA)-based scaffolds. Mesenchymal stem ... -
The influence of cellular patterning on brown adipogenic differentiation from mouse embryonic stem cells
Dias, Andrew (Rensselaer Polytechnic Institute, Troy, NY, 2015-08)A method for fabricating 3D microcapsules via LDW was developed, with excellent size control of encapsulated embryoid bodies. While cells could grow in 3D in these environments, they did not appear to survive differentiation ... -
Toward development of a cell-derived engineered synovial fluid for protection of cartilage matrix
Abu-Hakmeh, Ahmad Emad (Rensselaer Polytechnic Institute, Troy, NY, 2018-08)Osteoarthritis (OA) is an irreversible degenerative joint disease characterized by low-grade inflammation, mechanical inferiority, and structural changes to the various joint tissues. At the center of OA progression is the ... -
Toward development of a potassium (K+)-based intra-articular injection for osteoarthritis treatment
Erndt-Marino, Joshua Dean (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Osteoarthritis (OA) is characterized by a slow progression of cartilage erosion driven in part by a cascade of inflammatory mediators produced from an activated synovium and the cartilage itself. Chondrocytes lose their ... -
Toward therapeutic applications using mesenchymal stem cells: bone defect repair and immunoregulation
Arabiyat, Ahmad (Rensselaer Polytechnic Institute, Troy, NY, 2021-05)This motivated the development of cell-free approaches to employ the therapeutic qualities of the MSC secretome sans the challenges associated with cell-based approaches. In these contexts, the overarching goals of this ...