Browsing RPI Theses Online (Complete) by Issue Date
Now showing items 1-20 of 3764
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Protein developability and downstream bioprocessing : from predictive tools to mechanistic analysis
(Rensselaer Polytechnic Institute, Troy, NY, 2022-09)Although protein therapeutics, especially monoclonal antibodies (mAb), have raised tremendous attention in recent decades due to their efficacy in treating a wide range of diseases, they often face a number of development ... -
Semantically enabled medical image understanding
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Medical imaging examination is the most common form of routine medical analysis, which involves several stages of reasoning and careful analysis to reach a final decision by the radiologist. Most deep learning frameworks ... -
Cell free production of isobutanol
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)With a need for greener fuels, research into production of biofuels is essential. Isobutanol out preforms ethanol in key metrics such as engine compatibility, energy density, and gasoline blending. Current biofuel strategies ... -
Gaze, steering, and active vision during skilled quadcopter flight
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Previous accounts of how humans locomote have focused on movements and perceptualjudgments along the 2D ground plane, such as when driving automobiles or walking over various types of terrain. Humans, however, can also ... -
Privacy preservation and evaluation in machine learning
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)This thesis aims at improving methods for preserving privacy in machine learning for both generative and predictive models, and evaluating the privacy lost. Creating useful machine learning models requires the use of ... -
Modeling the viscosity and solubility of protein solutions
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Viscosity and solubility are one of the most important physical properties integral to the manufacturing and use of nearly every consumer product. The formulation of materials ranging from toothpastes to therapeutic drugs ... -
Incorporating external knowledge into food representation and recommendation
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Food is our most basic need, the very stuff of life. Food is fundamental for human beings and eating well is essential to good health. Food computing has attracted great interest from various fields. Representing food as ... -
Comprehensive, explainable, ml-based molecular toxicity and protein-ligand binding predictions
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Machine Learning (ML) and computer aided drug design have widely been considered to accelerate and focus the time-consuming and costly drug discovery process. In this work, we have used ML tools to improve early-stage drug ... -
Machine learning in health informatics
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)This dissertation concerns applications of Machine learning in health informatics. With an eye on personalized care as a main driver, we contribute on the following topics, (i) interpretable AI with applications in ... -
A methodology to evaluate equity in resource accessibility
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Inequalities present in society have been of increased interest in recent years, particularly in the United States. One source of inequality is unequal access to important resources, such as shopping. Recent developments ... -
Reduced-order modeling of neutron transport by proper generalized decomposition
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)The numerical simulation of neutron transport within a nuclear reactor—for brevity, reactor physics—is the foundation on which analysts: design new reactors; license existing designs; prolong the licenses of operating ... -
Building integrated agriculture simulation (BIA-sim) development of a simulation based software for the implementation of building integrated agriculture in urban contexts
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Since the world's population is growing at an alarming rate, scientists and researchers are trying to find ways to increase both the quality and quantity of food available. However, the current methods used in the agriculture ... -
Protease-catalyzed synthesis of N-acryloyl-oligopeptides and histidine-containing oligopeptides
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Synthetic peptides, peptides built via chemical methodology or through recombinant technology, have been designed for use in therapeutics. Current chemical methods to create synthetic peptides rely largely on solid-phase ... -
Augmenting collaborative immersive systems through cognitive technologies for educational scenarios
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Virtual reality continues to proliferate in the classroom. Human-scale immersive virtual environments provide natural benefits and assuage many of the issues raised with head-mounted displays. While a headset removes a ... -
Elucidating the causal mechanisms of Alzheimer's disease using cell-based models
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)The lack of a preventive therapy for neurodegenerative diseases, such as Alzheimer’s Disease (AD) has increased the urgency for gaining an understanding of the mechanisms that lead to cognitive decline and eventually death. ... -
The impact of surface modification on magneto-functional iron oxide – polyethylene oxide nanocomposites
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Remote triggering of smart materials such as shape memory polymers and nanocomposites for drug delivery are research areas of continued interest for magneto-functional nanocomposites. Magnetically susceptible nanoparticles ... -
Data-driven methods for probabilistic fault diagnosis in multirotor aircraft
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)The next revolution in aviation is upon us with advances in novel configurations of electric vertical take-off and landing (eVTOL) aircraft. Advanced air mobility (AAM) will offer on-demand services for human and cargo ... -
Dynamic methods for matching requests to suppliers in transportation platforms
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Peer-to-peer transportation platforms dynamically match requests (e.g., a ride, a delivery) to independent suppliers. A central challenge is how to make these matching decisions that can accommodate the different needs ... -
Three essays on data breaches and hospital operations : examining relationships with operating performance, it investments, and patient choice
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)The importance of information in modern society cannot be overemphasized. The entry into the information society created the new opportunities for firms and the convenience for customers, but at the same time created an ... -
Development of experimental and analytical methods for low-rate (α,n) neutron source characterization
(Rensselaer Polytechnic Institute, Troy, NY, 2022-08)The production of (α,n) neutrons occurs intrinsically for many important nuclear materials which contain actinide species and low-mass nuclides. Actinides are fundamentally radioactive due to instability caused by their ...