Browsing RPI Theses Open Access by Author "Hahn, Mariah"
Now showing items 1-7 of 7
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Engineered micro and nanotopography for neuron and glial guidance after spinal cord injury
Johnson, Christopher David Landis (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Spinal cord injury presents many barriers to regeneration that have yet to be solved. Guidance conduits are a promising approach that allow regenerating tissue to bypass or traverse the injury site. Peripheral nerve ... -
Enhancing drug delivery from electrospun fiber scaffolds for neural tissue engineering
D'Amato, Anthony R. (Rensselaer Polytechnic Institute, Troy, NY, 2018-12)The final aim in this study details the creation of an entirely new polymer that is made out of E2. With the help of Dr. Palermo’s lab, I synthesized a new, slowly-degrading E2 and polyethylene glycol (PEG) copolymer (PPEAP) ... -
Human endothelial cell response to thromboresistant collagen-mimetic hydrogels
Malmut, Sarah (Rensselaer Polytechnic Institute, Troy, NY, 2014-08)To address these issues, Browning et al. have developed a composite vascular graft composed of an electrospun mesh that acts as a reinforcing outer layer and a non-thrombogenic inner hydrogel-based layer that promotes ... -
Non-canonical cell stress in osteogenesis imperfecta
Gorrell, Laura (Rensselaer Polytechnic Institute, Troy, NY, 2021-05)We used this model to demonstrate noncanonical quality control of PC1 folding. Like other secretory proteins, PC1 misfolds and accumulates in the lumen of endoplasmic reticulum (ER), disrupting the function of this crucial ... -
Toward development of a cell-derived engineered synovial fluid for protection of cartilage matrix
Abu-Hakmeh, Ahmad Emad (Rensselaer Polytechnic Institute, Troy, NY, 2018-08)Osteoarthritis (OA) is an irreversible degenerative joint disease characterized by low-grade inflammation, mechanical inferiority, and structural changes to the various joint tissues. At the center of OA progression is the ... -
Toward development of a potassium (K+)-based intra-articular injection for osteoarthritis treatment
Erndt-Marino, Joshua Dean (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Osteoarthritis (OA) is characterized by a slow progression of cartilage erosion driven in part by a cascade of inflammatory mediators produced from an activated synovium and the cartilage itself. Chondrocytes lose their ... -
Towards biology-driven strategies for stem cell therapy applications
Kamaldinov, Timothy (Rensselaer Polytechnic Institute, Troy, NY, 2020-05)Towards the second goal, we demonstrate that MSCs can be selectively enriched using mitochondrial and plasma membrane potential indicators. Electrically enriched MSCs are phenotypically distinct cells with distinct ...