Browsing RPI Theses Open Access by Author "Karande, Pankaj"
Now showing items 1-9 of 9
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Aggregation and binding: a fundamental study of amyloid and antimicrobial peptides
Murray, Brian (Rensselaer Polytechnic Institute, Troy, NY, 2016-05)For amyloidogenic peptides, their adverse health effects are primarily derived from their ability to aggregate into small oligomers and subsequently large fibrils. Here, an aggrega-tion reaction model is developed in order ... -
Developing downstream bioprocessing for gene and cell therapy applications
Ghosh, Ronit (Rensselaer Polytechnic Institute, Troy, NY, 2021-08)With the recent progress in gene and cell-based regenerative therapies, the challenge of producing pure and concentrated stocks of complex biologicals, in particular, gene therapy vectors and functional cells, has gained ... -
Investigation into the thermodynamic and molecular basis of protein-ligand interactions in multimodal chromatography
Gudhka, Ronak Bharat (Rensselaer Polytechnic Institute, Troy, NY, 2020-08)The drive towards process intensification and the increased complexity of new classes of biological products has catalyzed significant interest in new bioseparation modalities. Multimodal chromatography has been shown to ... -
Mass spectrometry analysis of glycosaminoglycans and applications in biological research
Han, Xiaorui (Rensselaer Polytechnic Institute, Troy, NY, 2020-05)The glycosaminoglycan (GAG) family of polysaccharides includes the unsulfated hyaluronan and sulfated heparin, heparan sulfate, keratan sulfate, and chondroitin/dermatan sulfate. GAGs are involved in various biological ... -
Metabolic engineering and applied enzymology for the preparation of nutraceutical/ pharmaceutical chondroitin sulfate
He, Wenqin (Rensselaer Polytechnic Institute, Troy, NY, 2017-05)Chondroitin sulfate (CS) is an important glycosaminoglycan that is predominantly present in cartilage and the surfaces of many cells and extracellular matrices. It has been widely used in treating osteoarthritis due to its ... -
Particles in fluids : from the synthesis, properties and applications of micro-emulsions, Janus particles to microrheology
Chatterjee, Purba (Rensselaer Polytechnic Institute, Troy, NY, 2017-08)Particles at fluid interfaces can also be engineered to obtain smart materials such as "Janus" particles or particles which have "two faces" by virtue of differences in their surface chemistry and composition giving rise ... -
Quantitative understandings of human in vitro drug response relationships to in vivo model systems
Bruckner, Dylan M. (Rensselaer Polytechnic Institute, Troy, NY, 2019-12)Drug development is inefficient and expensive, with less than 10% of drug candidates entering clinical trials proceeding to market, and each costing an estimated $2.5 billion. This inefficiency is due to several reasons, ... -
Sequence-based separation of single-stranded DNA in capillary zone electrophoresis
Zhao, Jia (Rensselaer Polytechnic Institute, Troy, NY, 2018-08)This thesis explores further the mechanism for the sequence-based separation. First, the fluorescence tag attached to DNA was investigated as the cause of the sequenced-based separation. The same migration order was observed ... -
Strategies for the development of integrated purification processes for non-platform biologic therapeutics
Timmick, Steven Michael (Rensselaer Polytechnic Institute, Troy, NY, 2017-08)In the first approach, a multiscale platform for the discovery of peptide affinity chromatography ligands was developed and applied for the purification of human growth hormone (hGH) from yeast cultures. A high-throughput ...