Browsing RPI Theses Open Access by Author "Makhatadze, George I."
Now showing items 1-8 of 8
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Elucidating the role of multimodal ligand surfaces in protein chromatography using molecular dynamics simulations
Vats, Mayank (Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Over the past several years, protein-based therapeutics have revolutionized the pharmaceutical industry, with applications for treatment of a range of diseases from autoimmune to cancer. This rise has been accompanied by ... -
Functional characterization of autocatalytic proteins: green fluorescent protein And mycobacterial SufB intein
Nayak, Sasmita (Rensselaer Polytechnic Institute, Troy, NY, 2012-12) -
Investigation of the ion networks in pseudomonas aeruginosa : roles in physiology and pathogenesis
Foreman, Sara (Rensselaer Polytechnic Institute, Troy, NY, 2020-12)Growth defects range in intensity, and phenotypic changes vary by mutant, however the results of this characterization point to a greater role for these ion transporters in the regulation of pathogenesis in P. aeruginosa. ... -
Molecular determinants of the effects of hydrostatic pressure on proteins and nucleic acids and their temperature dependence
Chen, Calvin Rong-sen (Rensselaer Polytechnic Institute, Troy, NY, 2017-08)Piezophiles are extremophilic organisms that have evolved to survive at high hydrostatic pressures. They can be found at ocean depths of 11,000 meters where pressures reach 1,100 atmospheres and can even survive deep within ... -
Probing determinants of protein folding cooperativity
Jenkins, Kelly Anne (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Here we probe the effects of internal cavities on folding pathways and cooperativity of a model linear repeat protein, pp32. For WT pp32, high pressure NMR experiments revealed that cooperativity was highest at 293K, and ... -
Proteins under confinement: structure, dynamics and thermodynamics
Tian, Jianhui (Rensselaer Polytechnic Institute, Troy, NY, 2010-05) -
Solution nuclear magnetic resonance studies of proteins involved in Alzheimer's disease
Connors, Christopher Ryan (Rensselaer Polytechnic Institute, Troy, NY, 2013-08)As an intrinsically disordered protein (IDP), the Aß monomer is unsuitable for traditional, experimental structure determination methods. This has excluded Aß from molecular docking studies that are routinely performed ... -
Template-free protein structure prediction by coarse-grained hierarchical folding
Buck, Patrick (Rensselaer Polytechnic Institute, Troy, NY, 2010-08)