Browsing RPI Theses Open Access by Author "Wang, Chunyu"
Now showing items 1-8 of 8
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Biophysical characterization of intrinsically disordered peptides through molecular dynamics simulations and solution nuclear magnetic resonance spectroscopy
Rosenman, David Jacob (Rensselaer Polytechnic Institute, Troy, NY, 2015-08)Here, the ensembles of Aβ were simulated using all atom models and explicit water. Further, we employed enhanced sampling through replica exchange molecular dynamics (REMD) using longer timescales than had been employed ... -
Drug discovery for Alzheimer's disease targeting the transmembrane domain of amyloid precursor protein (AAPTM).
Eden, Angela Bailey (Rensselaer Polytechnic Institute, Troy, NY, 2022-08)Alzheimer’s Disease (AD) is a neurological disease currently affecting close to 6 million Americans (3). A major neuropathological hallmark of AD is the presence of senile plaques in the cerebral cortex and hippocampus ... -
Functional characterization of autocatalytic proteins: green fluorescent protein And mycobacterial SufB intein
Nayak, Sasmita (Rensselaer Polytechnic Institute, Troy, NY, 2012-12) -
NMR structural studies of FAD mutations in APPTM and amyloid-β peptide
Clemente, Nicolina Marie (Rensselaer Polytechnic Institute, Troy, NY, 2017-12)Aβ protein is the main aggregate component found in senile plaque in the AD brain. Familial Alzheimer’s disease (FAD) point mutations found within the Aβ sequence are known to cause early onset AD that occurs prior to the ... -
Probing determinants of protein folding cooperativity
Jenkins, Kelly Anne (Rensselaer Polytechnic Institute, Troy, NY, 2018-05)Here we probe the effects of internal cavities on folding pathways and cooperativity of a model linear repeat protein, pp32. For WT pp32, high pressure NMR experiments revealed that cooperativity was highest at 293K, and ... -
Proteins under confinement: structure, dynamics and thermodynamics
Tian, Jianhui (Rensselaer Polytechnic Institute, Troy, NY, 2010-05) -
Solution nuclear magnetic resonance studies of proteins involved in Alzheimer's disease
Connors, Christopher Ryan (Rensselaer Polytechnic Institute, Troy, NY, 2013-08)As an intrinsically disordered protein (IDP), the Aß monomer is unsuitable for traditional, experimental structure determination methods. This has excluded Aß from molecular docking studies that are routinely performed ... -
Understanding the mechanism of polyphenolic inhibition on human vascular NADPH oxidase
Yu, Jingjing (Rensselaer Polytechnic Institute, Troy, NY, 2007-12)