Browsing The Linhardt Research Labs by Title
Now showing items 709-728 of 1022
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Parameters Affecting the Efficiency of Affinity-Based Reversed Micellar Extraction and Separation
(1997-07-01)Parameters affecting the efficiency of affinity-based reversed micellar extraction and separation (ARMES) in glycoprotein purification -
Parent heparin and daughter LMW heparin correlation analysis using LC-MS and NMR
(2017-04-08)Heparin is a structurally complex, polysaccharide anticoagulant derived from livestock, primarily porcine intestinal tissues. Low molecular weight (LMW) heparins are derived through the controlled partial depolymerization ... -
Partial depolymerization of pectin by photochemical reaction
(2010-06-16)Complex heterogeneous polysaccharides that comprise pectin were partially depolymerized by a photochemical reaction using ultraviolet light in the presence of titanium dioxide catalyst. In a period of 6h at pH 7, this ... -
Patents related to Dengue Virus Infection
(2002-08-01)This review discusses patents relevant to dengue virus infection. Dengue virus is a mosquito-transmitted flavivirus that usually causes an acute self-limited febrile illness, but may result in more severe life threatening ... -
Pathogenesis and inhibition of flaviviruses from a carbohydrate perspective
(Multidisciplinary Digital Publishing Institute (MDPI), 2017-06-01)Flaviviruses are enveloped, positive single stranded ribonucleic acid (RNA) viruses with various routes of transmission. While the type and severity of symptoms caused by pathogenic flaviviruses vary from hemorrhagic fever ... -
Pattern and Spacing of Basic Amino Acids in Heparin Binding Sites
(1997-07-01)Glycosaminoglycan (GAG)-protein interactions regulate a myriad of physiologic and pathologic processes, yet an understanding of how these molecules interact is lacking. The role of the pattern and spacing of basic amino ... -
PBN11-8, a cytotoxic polypeptide purified from marine Bacillus, suppresses invasion of human hepatocellular carcinoma cells by targeting focal adhesion kinase pathways
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-01-01)The development of antitumor drugs has attracted cancer researchers and the identification of novel antitumor lead compounds is certainly of great interest. The fermentation broth of Bacillus sp. N11-8, which was isolated ... -
Pectic oligosaccharides hydrolyzed from citrus canning processing water by Fenton reaction and their antiproliferation potentials
(2019-03-01)Citrus canning processing water contains a valuable and renewable source of biopolymers and bioactive compounds including pectic polysaccharides. Upgrading these processing wastes can not only alleviate environmental ... -
PEDOT:PSS-coated polybenzimidazole electroconductive nanofibers for biomedical applications
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-08-02)Bioelectricity drives several processes in the human body. The development of new materials that can deliver electrical stimuli is gaining increasing attention in the field of tissue engineering. In this work, novel, highly ... -
Perspective: 2003 Claude S. Hudson Award Address in Carbohydrate Chemistry. Heparin: Structure and Activity
(2003)Heparin, a sulfated polysaccharide, is a major clinical anticoagulant. It is exploited to overcome the natural propensity for blood to clot. Surgical procedures often require anticoagulation as do extracorporeal therapies, ... -
Pharmacokinetics and Pharmacodynamics of Oral Heparin Solid Dosage Form in Healthy Human Subjects
(American College of Clinical Pharmacology (ACCP), 2007-12-01)The present investigation determined the molecular structure and the pharmacokinetic and pharmacodynamic profiles of oral unfractionated heparin containing oral absorption enhancer sodium N-[8-(2-hydroxybenzoyl) amino]caprylate, ... -
Photochemical preparation of a novel low molecular weight heparin
(Elsevier, 2012-01-15)Commercial low molecular weight heparins (LMWHs) are prepared by several methods including peroxidative cleavage, nitrous acid cleavage, chemical ß-elimination, and enzymatic β-elimination. The disadvantages of these methods ... -
Photolytic depolymerization of alginate
(2009-10-12)A photochemical reaction has been developed for the partial de-polymerization of sodium alginate, a polysaccharide utilized in medicine, pharmacy, basic sciences and foods. An aqueous solution of sodium alginate was ... -
Physical Stabilization of Acidic Fibroblast Growth Factor by Polyanions
(1993-01-01)Acidic fibroblast growth factor (aFGF) is markedly stabilized by heparin. Partially due to the heterogeneity of heparin preparations, the nature of the aFGF polyanion binding site is still ill-defined. We have, therefore, ... -
Physicochemical properties and conformations of water-soluble peach gums via different preparation methods
(2019-10-01)Physicochemical properties and conformations of WEPG (water extracted peach gum), AEPG2.0 (alkali extracted peach gum, 2 M NaOH) and HPPG8 (H2O2 extracted peach gum, 8 h), prepared from the gum of Prunus persica Batsch, ... -
Physiological, Pathophysiological and Therapeutic Roles of Heparin/Heparan Sulfate
(2008-12-01)Heparin and heparan sulfate belong to the glycosaminoglycan (GAG) family of carbohydrates. They are linear acidic complex polysaccharides found on the cell surface and in the extracellular matrix. Heparin and heparan sulfate ... -
Platelet factor 4 polyanion immune complexes: Heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia
(Springer, 2021-12-01)Background: This is a review article on heparin-induced thrombocytopenia, an adverse effect of heparin therapy, and vaccine-induced immune thrombotic thrombocytopenia, occurring in some patients administered certain ... -
Poly(ethylene glycol)-Based Biosensor Chip to Study Heparin Protein Interactions
(2005)Heparin’s role in biological processes is commonly mediated by its interaction with proteins [1]. During the past decade, our research group has relied on surface plasmon resonance (SPR)1 to monitor heparin–protein ... -
Poly-ion complex formation of heparin and tetrakis (3-aminopropyl) ammonium allows the sustained release of unfractionated heparin
(Elsevier, 2020)Physical mixtures of cationic polymers and heparin have been developed to overcome the limitations of unfractionated heparin. In this study, we found that heparin associates with natural polyamines in water, resulting in ... -
Poly-ion Complex of Chondroitin Sulfate and Spermine and its Effect on Oral Chondroitin Sulfate Bioavailability
(2016-01-01)Chondroitin sulfate (CS) has been accepted as an ingredient in health foods for the treatment of symptoms related to arthritis and cartilage repair. However, CS is poorly absorbed through the gastrointestinal tract because ...