Browsing The Linhardt Research Labs by Title
Now showing items 322-341 of 1022
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Electron Capture Dissociation, Electron Detachment Dissociation, and Infrared Multiphoton Dissociation of Sucrose Octasulfate
(Sage, 2009-04-30)The structural analysis of sulfated carbohydrates such as glycosaminoglycans (GAGs) has been a long- standing challenge for the field of mass spectrometry. The dissociation of sulfated carbohydrates by collisionally- ... -
Electron detachment dissociation and infrared multiphoton dissociation of heparin tetrasaccharides
(Elsevier, 2011-12-01)Heparin glycosaminoglycans (GAGs) present the most difficult glycoform for analytical characterization due to high levels of sulfation and structural heterogeneity. Recent contamination of the clinical heparin supply and ... -
Electron Detachment Dissociation of Dermatan Sulfate Oligosaccharides
(American Chemical Society (ACS), 2008-02-01)The structural characterization of glycosaminoglycans (GAG) oligosaccharides has been a long-standing challenge in the field of mass spectrometry. In this work, we present the application of electron detachment dissociation ... -
Electron Detachment Dissociation of Glycosaminoglycan Tetrasaccharides
(American Chemical Society (ACS), 2007)The first application of electron detachment dissociation (EDD) to carbohydrates is presented. The structural characterization of glycosaminoglycan (GAG) oligosaccharides by mass spectrometry is a longstanding problem ... -
Electron Induced Dissociation of Glycosaminoglycan Tetrasaccharides
(American Chemical Society (ACS), 2008-10-01)Electron detachment dissociation (EDD) Fourier transform mass spectrometry has recently been shown to be a powerful tool for examining the structural features of sulfated glycosaminoglycans (GAGs). The characteristics of ... -
Electrophoresis for the Analysis of Acidic Oligosaccharides
(2000-08-01)Carbohydrates are the most abundant species among the biopolymers and have recently been actively studied as important biological molecules (1). Acidic oligosaccharides play especially important biological roles, including ... -
Electrophoresis for the analysis of heparin purity and quality
(Wiley, 2012-06-01)The adulteration of raw heparin with oversulfated chondroitin sulfate (OSCS) in 2007–2008 produced a global crisis resulting in extensive revisions to the pharmacopeia monographs and prompting the FDA to recommend the ... -
Electrospinning from room temperature ionic liquids for biopolymer fiber formation
(2010-11-03)Polymer electrospinning has emerged as a powerful technique for the fabrication of nanofibrous materials with high specific surface areas, controllable compositions, and high porosities for a wide range of applications. ... -
Electrospinning of nanomaterials and applications in electronic components and devices
(2010-09-01)Electrospinning of nanomaterial composites are gaining increased interest in the fabrication of electronic components and devices. Performance improvement of electrospun components results from the unique properties ... -
Electrospinning: a novel nano-encapsulation approach for bioactive compounds
(2017-12-01)Background: Bioactive compounds have gained increasing attention for their health benefits. However, the instability of bioactive compounds during food processing and storage, and low bioavailability or chemical instability ... -
Electrospray ionization Fourier transform mass spectrometric analysis of intact bikunin glycosaminoglycan from normal human plasma
(2011-08-15)A mixture of glycosaminoglycan (GAG) chains from a plasma proteoglycan bikunin was fractionated using native, continuous-elution polyacrylamide gel electrophoresis, and the resulting fractions were analyzed by electrospray ... -
Electrospun polyvinylpyrrolidone fibers with high concentrations of ferromagnetic and superparamagnetic nanoparticles
(2011-06-22)Electrospun polymer fibers were prepared containing mixtures of different proportions of ferromagnetic and superparamagnetic nanoparticles. The magnetic properties of these fibers were then explored using a superconducting ... -
Elucidating the Unusual Reaction Kinetics of D-Glucuronyl C5-Epimerase
(2020-11-01)The chemoenzymatic synthesis of heparin, through a multienzyme process, represents a critical challenge in providing a safe and effective substitute for this animal-sourced anticoagulant drug. D-glucuronyl C5-epimerase ... -
Encapsulation of bioactive compound in electrospun fibers and its potential application
(2017-10-25)Electrospinning is a simple and versatile encapsulation technology. Since electrospinning does not involve severe conditions of temperature or pressure or the use of harsh chemicals, it has great potential for effectively ... -
Encapsulation of phycocyanin by prebiotics and polysaccharides-based electrospun fibers and improved colon cancer prevention effects
(2020-04-15)To preserve bioactivity and achieve colon targeted release of phycocyanin (PC), the polysaccharides-based electrospun fiber mat (EFM) containing PC and prebiotics was prepared and characterized. In vitro release tests ... -
End-functionalised glycopolymers as glycosaminoglycan mimetics inhibit HeLa cell proliferation
(2020-08-07)The glycosaminoglycans (GAGs) on cell surfaces play significant roles during cancer development, and the heparanase activity is strongly implicated in the structural remodeling of the extracellular GAG matrix, potentially ... -
Endothelial glycocalyx shedding predicts donor organ acceptability and is associated with primary graft dysfunction in lung transplant recipients
(2019-06-01)Background: The endothelial glycocalyx, a sieve-like structure located on the luminal surface of all blood vessels, has been found to be integral to regulation of capillary permeability and mechanotransduction. Given this, ... -
Engineered heparins as new anticoagulant drugs
(Wiley, 2016)Heparin is an anionic polysaccharide that is widely used as a clinical anticoagulant. This glycosaminoglycan is prepared from animal tissues in metric ton quantities. Animal-sourced heparin is also widely used in the ... -
Engineering of routes to heparin and related polysaccharides
(Springer, 2012-01-01)Anticoagulant heparin has been shown to possess important biological functions that vary according to its fine structure. Variability within heparin's structure occurs owing to its biosynthesis and animal tissue-based ... -
Enhanced mandrel design for electrospinning aligned fiber mats from low volatility solvents
(2021-03-01)A cylindrical mandrel with axially aligned rods was designed and tested for the collection of electrospun fibers. Blended polyaniline/polyethylene oxide fibers were electrospun from a solution containing a nonvolatile ...