Browsing The Linhardt Research Labs by Title
Now showing items 409-428 of 1022
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Fucosylated chondroitin sulfate oligosaccharides exert anticoagulant activity by targeting at intrinsic tenase complex with low FXII activation: importance of sulfation pattern and molecular size
(2017-01-01)Fucosylated chondroitin sulfates (fCSs) are structurally unusual glycosaminoglycans isolated from sea cucumbers that exhibit potent anticoagulant activity. These fCSs were isolated from sea cucumber, Isostichopus badionotus ... -
Fucosylated chondroitin sulfate oligosaccharides from Isostichopus badionotus regulates lipid disorder in C57BL/6 mice fed a high-fat diet
(2018-12-01)Fucosylated chondroitin sulfate (fCS) and its depolymerized derivative (DfCS), prepared from sea cucumbers, are well-known for their anticoagulant activity. However, their other functional activities are poorly understood. ... -
Full recovery of value-added compounds from citrus canning processing water
(2018-03-01)In the production of canned citrus, large amounts of processing water were discharged during the segment membrane removal process, causing severe pollution. In order to reduce pollution and recover the bioactive compounds ... -
Functional chondroitin sulfate from Enteroctopus dofleini containing a 3-O-sulfo glucuronic acid residue
(2015-08-24)There are several reports that chondroitin sulfate containing K-type units [GlcA (3S)-GalNAc (4S)] exhibiting similar levels of neurite outgrowth promoting activities as CS having high amounts of B-, D- and E-type disulfated ... -
Functional role of glycosaminoglycans in decellularized lung extracellular matrix
(Elsevier, 2020-01-15)Despite progress in use of decellularized lung scaffolds in ex vivo lung bioengineering schemes, including use of gels and other materials derived from the scaffolds, the detailed composition and functional role of ... -
Functionalization of electrospun nanofibers and fiber alignment enhance neural stem cell proliferation and neuronal differentiation
(Frontiers Media SA, 2020-10-26)Neural stem cells (NSCs) have the potential to generate the cells of the nervous system and, when cultured on nanofiber scaffolds, constitute a promising approach for neural tissue engineering. In this work, the impact of ... -
Gas-Phase Examination of the Complex of Fibroblast Growth Factor 1 with Heparan Sulfate: a Traveling Wave Ion Mobility Spectrometry (TWIMS) and Molecular Modeling Study
(American Chemical Society (ACS), 2017)Fibroblast growth factors (FGFs) regulate several cellular developmental processes by interacting with cell surface heparan proteoglycans and transmembrane cell surface receptors (FGFR). The interaction of FGF with heparan ... -
Gelling mechanism of RG-I enriched citrus pectin: Role of arabinose side-chains in cation- and acid-induced gelation
(2020-04-01)RG-I enriched pectin is present in fruit and vegetable containing products. However, it is removed by the hot acid treatment during commercial pectin production to improve gelling properties and to afford a more uniform ... -
Geometrical characteristics of eggs from three poultry species
(Elsevier, 2021)We studied the correlations between egg geometrical parameters (i.e., egg shape index, sphericity, geometric mean diameter, surface area, and volume) and eggshell qualities, or the organic matrix in eggshell. Eggs were ... -
Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7
(2017-07-05)Heparan sulfate proteoglycans activate the matrix metalloproteinase-7 zymogen (proMMP-7) and recruit it in order to shed proteins from cell surfaces. This occurs in uterine and mammary epithelia, bacterial killing, lung ... -
Glycan Determinants of Heparin-Tau Interaction
(2017-03-14)Tau aggregates into paired helical filaments within neurons, a pathological hallmark of Alzheimer's disease. Heparin promotes tau aggregation and recently has been shown to be involved in the cellular uptake of tau aggregates. ... -
Glycan Markers of Human Stem Cells Reassigned with Beam Search Arrays
(The American Society for Biochemistry and Molecular Biology, Inc., 2019)Glycan antigens recognized by monoclonal antibodies have served as stem cell markers. To understand regulation of their biosynthesis and their roles in stem cell behavior precise assignments are required. We have applied ... -
GlycCompSoft: Software for automated comparison of low molecular weight heparins using top-down LC/MS data
(Public Library of Science (PLoS), 2016-12-01)Low molecular weight heparins are complex polycomponent drugs that have recently become amenable to top-down analysis using liquid chromatography-mass spectrometry. Even using open source deconvolution software, DeconTools, ... -
Glycocalyx-like hydrogel coatings for small diameter vascular grafts
(2020-06-01)Novel biological vascular conduits, such as decellularized tissue engineered vascular grafts (TEVGs) are hindered by high thrombogenicity. To mimic the antithrombogenic surface of native vessels with a continuous ... -
Glycoconjugate synthesis using chemoselective ligation
(Royal Society of Chemistry, 2019-01-01)Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a ... -
Glycolipid-containing nanoparticle vaccine engages invariant NKT cells to enhance humoral protection against systemic bacterial infection but abrogates T-independent vaccine responses
(2021-04-15)CD4+ T cells enable the critical B cell humoral immune protection afforded by most effective vaccines. We and others have recently identified an alternative source of help for B cells in mice, invariant NK T (iNKT) cells. ... -
Glycomics of Proteoglycan Biosynthesis in Murine Embryonic Stem Cell Differentiation
(American Chemical Society (ACS), 2007-11-01)Glycosaminoglycans (GAGs) play a critical role in binding and activation of growth factors involved in cell signaling critical for developmental biology. The biosynthetic pathways for GAGs have been elucidated over the ... -
Glycosaminoglycan characterization by electrospray ionization mass spectrometry including Fourier transform mass spectrometry
(Elsevier, 2010-01-01)Electrospray ionization mass spectrometry (ESI MS) is a versatile analytical technique in glycomics of glycosaminoglycans (GAGs). Combined with enzymology, ESI MS is used for assessing changes in disaccharide composition ... -
Glycosaminoglycan compositional analysis of relevant tissues in ZIKV pathogenesis and in vitro evaluation of heparin as antiviral against ZIKV infection
(American Chemical Society (ACS), 2019)Zika virus (ZIKV) is an enveloped RNA virus from the flavivirus family that can cause fetal neural abnormalities in pregnant women. Previously, we established that ZIKV-EP (envelope protein) binds to human placental ... -
Glycosaminoglycan disaccharide compositional analysis of cell-derived extracellular matrices using liquid chromatography-tandem mass spectrometry
(2020-01-01)Cell-derived extracellular matrices have emerged as promising scaffolds for tissue engineering (TE) strategies due to their ability to create a biomimetic microenvironment providing biochemical and physical cues to cells, ...