Browsing The Linhardt Research Labs by Title
Now showing items 569-588 of 1022
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Intrinsically disordered N-terminal domain (NTD) of p53 interacts with mitochondrial PTP regulator Cyclophilin D
(Elsevier, 2022)Mitochondrial permeability transition pore (mPTP) plays crucial roles in cell death in a variety of diseases, including ischemia/reperfusion injury in heart attack and stroke, neurodegenerative conditions, and cancer. To ... -
Investigating changes in the gas-phase conformation of antithrombin III upon binding of Arixtra using traveling wave ion mobility spectrometry (TWIMS)
(2015)We validate the utility of ion mobility to measure protein conformational changes induced by the binding of glycosaminoglycan ligands, using the well characterized system of Antithrombin III (ATIII) and Arixtra, a ... -
Investigation of the Binding Mechanism between Internalin B and Heparin using Surface Plasmon Resonance
(American Chemical Society (ACS), 2007-03-13)Listeria monocytogenes, a food-borne pathogen that infects immunocompromised patients, enters and proliferates within mammalian cells by taking advantage of host cell machinery. While entry into macrophages and other ... -
IO4-- stimulated crosslinking of catechol-conjugated hydroxyethylchitosan as a tissue adhesive
(2019)Catechol-functionalized polymers are of particular interest because of their strong water-resistant adhesive properties. Hydroxymethyl chitosan (HECTS) has been used as an implantable biomaterial having good water solubility, ... -
Ionic Liquid Derived Blood Compatible Composite Membranes For Kidney Dialysis
(Wiley, 2006-11-01)A novel heparin- and cellulose-based biocomposite is fabricated by exploiting the enhanced dissolution of polysaccharides in room temperature ionic liquids (RTILs). This represents the first reported example of using a new ... -
Ionic Liquid Solvent Properties as Predictors of Lignocellulose Pretreatment Efficacy
(2010-11-03)Effective pretreatment of lignocellulosic biomass is vital to its bioconversion to a usable liquid fuel. A growing body of work has focused on using room temperature ionic liquids (RTILs) to pretreat lignocellulose for ... -
Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis
(2009-04-01)Lignocellulose represents a key sustainable source of biomass for transformation into biofuels and bio-based products. Unfortunately, lignocellulosic biomass is highly recalcitrant to biotransformation, both microbial and ... -
Ionic Liquids In Carbohydrate Chemistry – Current Trends And Future Directions
(2005-10-01)Room Temperature Ionic Liquids (RTILs) have recently been introduced as new solvents in the chemical and biotechnological arenas. Carbohydrates are important natural products that play important biological and commercial ... -
Is Human Placenta Proteoglycan Remodeling Involved in Pre-Eclampsia?
(Springer, 2008)Impaired placento-fetal communication is a coherent symptom of exaggerated pre-eclampsia. The impact of the cellular expression of different glycosaminoglycans (GAGs) in this event on the placenta in pre-eclampsia is still ... -
Ischemic stroke disrupts the endothelial glycocalyx through activation of proHPSE via acrolein exposure
(The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2020-12-25)Infiltration of peripheral immune cells after blood-brain barrier dysfunction causes severe inflammation after a stroke. Although the endothelial glycocalyx, a network of membrane-bound glycoproteins and proteoglycans that ... -
Isoflavonoid Production by Genetically Engineered Microorganisms
(2013-01-01)Isoflavonoids are a class of plant natural products gaining attention due to their pharmaceutical properties. These natural compounds constitute a subclass of flavonoids, which belong to a broader class of plant products ... -
Isoflavonoid production by genetically engineered microorganisms
(2013-01-01)Isoflavonoids are a class of plant natural products gaining attention due to their pharmaceutical properties. These natural compounds constitute a subclass of flavonoids, which belong to a broader class of plant products ... -
Isolation and Characterization of b-Cyclodextrin Sulfates by Preparative Gradient Polyacrylamide Gel Electrophoresis,Capillary Electrophoresis and Electrospray Ionization Mass Spectrometry
(1998)A beta-cyclodextrin sulfate mixture has been fractionated using discontinuous gradient polyacrylamide gel electrophoresis. Semidry electrotransfer of the sample onto a positively charged nylon membrane and visualization ... -
Isolation and Characterization of Heparan Sulfate from Crude Porcine Intestinal Mucosa Peptidoglycan Heparin
(1995)A method for the preparation of heparan sulfate from peptidoglycan heparin is described. The objective of this research was to provide a basis for the development and validation of an industrial process to support the ... -
Isolation and Characterization of Heparan Sulfate from Various Murine Tissues
(Springer, 2006-11-01)Heparan sulfate (HS), is a proteoglycan (PG) found both in the extracellular matrix and on cell surface. It may represent one of the most biologically important glycoconjugates, playing an essential role in a variety of ... -
Isolation and Characterization of Raw Heparin from Dromedary Intestine: Evaluation of a New Source of Pharmaceutical Heparin
(2003-01-01)Heparin, a heterogeneous anionic polysaccharide, is the glycosaminoglycan (GAG) used clinically an anticoagulant. This anticoagulant activity is primarily derived from its binding to the serine protease inhibitor antithrombin ... -
Isolation and Recovery of Acidic Oligosaccharides from Polyacrylamide Gels by Semi-Dry Electrotransfer
(1990-01-01)Acidic oligosaccharides derived from glycosaminoglycan heparin were separated by polyacrylamide gradient gel electrophoresis (PAGE). The gel could be visualized using Alcian Blue dye to give a pattern of highly resolved, ... -
Isolation and structural characterization of glycosaminoglycans from heads of red salmon (Oncorhynchus nerka)
(Jacobs, 2014)Glycosaminoglycans (GAGs) are linear, highly negatively charged polysaccharides. They are ubiquitous molecules exhibiting a wide range of biological functions with numerous applications in pharmaceutical, cosmetic, and ... -
Isolation of a lectin binding rhamnogalacturonan-I containing pectin from pumpkin
(2017)A rhamnogalacturonan-I (RG-I) containing pectic polysaccharide (PPc) was isolated from pumpkin following a low-temperature alkali treatment and a combination of gradual alcohol precipitation and ion-exchange. Monosaccharide ... -
Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding
(FEBS Press, 2013-05-01)Keratan sulfate (KS) is an important glycosaminoglycan that is found in cartilage, reproductive, and neural tissues. Corneal KS glycosaminoglycan is found N-linked to lumican, keratocan, and mimecan proteoglycans and has ...