Browsing The Linhardt Research Labs by Title
Now showing items 673-692 of 1022
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Neutralizing the anticoagulant activity of ultra-low molecular weight heparins using N-acetylglucosamine 6-sulfatase
(FEBS Press, 2013-05-01)Heparin has been the most commonly used anticoagulant drug for nearly a century. The drug heparin is generally categorized into three forms according to its molecular weight: unfractionated (UF, average molecular weight ... -
New Approaches for Anticoagulation in Extracorporeal Therapy
(1987-01-01)The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. Two approaches have been used to solve this problem. The first involves full heparinization of blood entering ... -
New Approaches for the Preparation of Hydrophobic Heparin Derivatives
(1994-01-01)A heparin derivative sufficiently lipophilic to be bound to plastics, forming blood-compatible supports, or to be used as an anticoagulant by transdermal or oral routes would be of great pharmaceutical interest. For such ... -
New functional tools for anti-thrombogenic activity assessment of live surface glycocalyx
(American Heart Association (AHA) Journals and Wiley, 2016)Objective: It is widely accepted that the presence of a glycosaminoglycan-rich glycocalyx is essential for endothelialized vasculature health; in fact, a damaged or impaired glycocalyx has been demonstrated in many vascular ... -
A New Glycosaminoglycan from the Giant African Snail Achatina fulica
(Elsevier, 1996)A new glycosaminoglycan has been isolated from the giant African snail Achatina fulica. This polysaccharide had a molecular weight of 29,000, calculated based on the viscometry, and a uniform repeating disaccharide structure ... -
New insights into the action of bacterial chondroitinase AC I and hyaluronidase on hyaluronic acid
(2017-02-20)Hyaluronic acid (HA), a glycosaminoglycan, is a linear polysaccharide with negative charge, composed of a repeating disaccharide unit [→4)-β-d-glucopyranosyluronic acid (1→3)-β-d- N-acetyl-d-glucoaminopyranose (1→]n ([→4) ... -
New Insights into the Heparan Sulfate Proteoglycan binding Activity of Apolipoprotein E4
(2001)Defective binding of apolipoprotein E (apoE) to heparan sulfate proteoglycans (HSPGs) is associated with increased risk of atherosclerosis due to inefficient clearance of lipoprotein remnants by the liver. The interaction ... -
New Ionic Liquid Matrix for Direct UV-MALDI-TOF-MS Analysis of Dermatan Sulfate and Chondroitin Sulfate Oligosaccharides
(American Chemical Society (ACS), 2007)Polyanionic oligosaccharides such as dermatan sulfate (DS) and chondroitin sulfate (CS) exhibit poor ionization efficiencies and tend to undergo thermal fragmentation through the loss of SO(3) under conventional ultraviolet ... -
New Methodologies in Heparin Structure Analysis and the Generation of Low Molecular Weight Heparins
(1992)This chapter examines the methods used to prepare heparin, low molecular weight (LMW) heparins, and immobilized heparins. These heparins and heparin derivatives arc polydispcrse heterogeneous mixtures that require structural ... -
New Potent Insecticidal Agent: 4’-Fucosyl Avermectin Derivative
(2004-09-06)A 4′-fucosyl avermectin derivative was designed and synthesized. This new avermectin derivative showed excellent in vivo bioactivity against cabbage larvae when compared to commercially available avermectin B1a. In this ... -
NMR quantification for monitoring heparosan K5 capsular polysaccharide production
(Elsevier, 2010)Traditional chromatographic quantification methods for heparosan produced from the Escherichia coli K5 strain rely on extensive purification requiring laborious sample preparation. These methods are time-consuming, often ... -
NMR Solution Conformation of Heparin-Derived Hexasaccharide
(1997-11-15)The solution conformation of homogeneous, heparin-derived hexasaccharide (residues A, B, C, D, E, F) has been investigated by using 1H-NMR spectroscopy. Intra-ring conformations have been defined by J-coupling constants ... -
NMR Solution Conformation of Heparin-Derived Tetrasaccharide
(1996-08-15)The solution conformation of the homogeneous, heparin-derived tetrasaccharide delta UA2S(1-->4)-alpha-D-GlcNpS6S(1-->4)-alpha-L-IdoAp2S (1-->4)-alpha-D-GlcNpS6S (residues A, B, C and D respectively, where IdoA is iduronic ... -
Non-anticoagulant heparin as a pre-exposure prophylaxis prevents Lyme disease infection
(American Chemical Society (ACS), 2020-03-13)Lyme disease (LD) is caused by the spirochete Borrelia burgdorferi sensu lato (Bbsl). After transmission to humans by ticks, Bbsl spreads to multiple organs, leading to arthritis, carditis, and neuroborreliosis. No effective ... -
Non-anticoagulant low molecular weight heparins for pharmaceutical applications
(2019-01-24)Heparin is a polypharmacological agent with anticoagulant activity. Periodate oxidation of the nonsulfated glucuronic acid residue results in non-anticoagulant heparin derivative (NACH) of reduced molecular weight. Similar ... -
Non-Random Structural Features in the Heparin Polymer
(1989)Computer simulation studies were used to prepare an ensemble of heparin number chains. The polydispersity of these chains was simulated by introducing a specific "fraction of terminators", and it closely resembled the ... -
Novel Cellulose – Halloysite Hemostatic Nanocomposite Fibers with a Dramatic Reduction in Human Plasma Coagulation Time
(2019-05-01)High-performance cellulose–halloysite hemostatic nanocomposite fibers (CHNFs) are fabricated using a one-step wet–wet electrospinning process and evaluated for human plasma coagulation by activated partial thromboplastin ... -
Novel interactions of glycosaminoglycans and bacterial glycolipids mediate binding of enterococci to human cells
(Elsevier, 2009-07-03)Enterococcus faecalis is among the most important nosocomial pathogens. The intestinal mucosa is considered to be the main site used by these bacteria for entrance and dissemination. A better understanding of the mechanisms ... -
Novel Method for Measurement of Heparin Anticoagulant Activity Using SPR
(Elsevier, 2017-06-01)A novel method has been developed for the easy measurement of heparin's anticoagulant activity using surface plasmon resonance. The anticoagulant activity of target heparin was evaluated by measuring the competitive ... -
Nucleolin: Acharan Sulfate-Binding Protein on the Surface of Cancer Cells
(Oxford, 2005-01-01)Glycosaminoglycans (GAGs) are complex polysaccharides that participate in the regulation of physiological processes through the interactions with a wide variety of proteins. Acharan sulfate (AS), isolated from the giant ...