Browsing The Linhardt Research Labs by Title

Now showing items 729-748 of 1022

    • Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2 

      Imamura, Masataka; Higashi, Kyohei; Yamaguchi, Katsutoshi; Asakura, Kiryu; Furihata, Tomomi; Terui, Yusuke; Satake, Toshihiko; Maegawa, Jiro; Yasumura, Kazunori; Ibuki, Ai; Akase, Tomoko; Nishimura, Kazuhiro; Kashiwagi, Keiko; Linhardt, Robert J.; Igarashi, Kazuei; Toida, Toshihiko (Nature, 2016-09-21)
      Polyamines release the let-7b-mediated suppression of initiation codon recognition during the protein synthesis of EXT2

    • Polyaniline-polycaprolactone blended nanofibers for neural cell culture 

      Garrudo, F.F.F.; Chapman, C.A.; Hoffman, P.; Udangawa, R.W.; Silva, J.C.; Mikael, P.E.; Rodrigues, C.A.V.; Cabral, J.M.S.; Morgado, J.M.F.; Ferreira, F.C.; Linhardt, Robert J. (2019-08-01)
      Neurodegenerative diseases compromise the quality of life of increasing numbers of the world’s aging population. While diagnosis is possible, no effective treatments are available. Using both tissue engineering and ...

    • Polyaniline-Polycaprolactone Fibers for Neural Applications: Electroconductivity Enhanced by Pseudo-Doping 

      Garrudo, F.F.F.; Mikael, P.E.; Rodrigues, C.A.V.; Udangawa, R.W.; Paradiso, P.; Chapman, C.A.; Hoffman, P.; Colaço, R.; Cabral, J.M.S.; Morgado, J.; Linhardt, Robert J.; Ferreir, F.C. (2021-01-01)
      Replenishing neurons in patients with neurodegenerative diseases is one of the ultimate therapies for these progressive, debilitating and fatal diseases. Electrical stimulation can improve neuron stem cell differentiation ...

    • Polybenzimidazole nanofibers for neural stem cell culture 

      Garrudo, F.F.F.; Udangawa, R.N.; Hoffman, P.R.; Sordini, L.; Chapman, C.A.; Mikael, P.E.; Ferreira, F.A.; Silva, J.C.; Rodrigues, C.A.V.; Cabral, J.M.S.; Morgado, J.M.F.; Ferreira, F.C.; Linhardt, Robert J. (Elsevier, 2019-12-01)
      Neurodegenerative diseases compromise the quality of life of an increasing number of people in the world's aging population. While diagnosis is possible, no effective treatments are available. Strong efforts are needed to ...

    • Polymer Based Drug Delivery: Magnetic Modulation and Bioerodible Systems 

      Edelmen, E.; Linhardt, Robert J.; Bobeck, H.; Kost, J.; Rosen, H.B.; Langer, R. (1984)
      Polymer based drug, delivery systems have been considered for many applications to supplement standard means of medical therapeutics. Currently nitroglycerin, scopolamine, progesterone, and pilocarpine [1] are being ...

    • Polymorphic factor H-binding activity of CspA protects Lyme disease borreliae from the host complement 

      Hart, T.; Nguyen, N.T.T.; Nowak, N.; Zhang, F.; Linhardt, Robert J.; Diuk-Wasser, M.; Ram, S.; Kraiczy, P.; Lin, Y.P. (Public Library of Science (PLoS), 2018)
      Borrelia burgdorferi sensu lato (Bbsl), the causative agent of Lyme disease, establishes an initial infection in the host's skin following a tick bite, and then disseminates to distant organs, leading to multisystem ...

    • Polysaccharide Sequence Influences the Specificity and Catalytic Activity of Glucuronyl C5-Epimerase 

      Vaidyanathan, Deepika; Ke, Xia; Yu, Yanlei; Linhardt, Robert J.; Dordick, Jonathan S. (2020-07-14)
      Heparin is a widely used biotherapeutic produced from animal tissues. However, it might be possible to produce a bioengineered version using a multienzyme process, relying on the isolation of the E. coli K5 capsule heparosan ...

    • Polysaccharide-based nanocomposites and their applications 

      Zheng, Y.; Monty, J.; Linhardt, Robert J. (Elsevier, 2015)
      Polysaccharide nanocomposites have become increasingly important materials over the past decade. Polysaccharides offer a green alternative to synthetic polymers in the preparation of soft nanomaterials. They have also been ...

    • Polysaccharides and phytochemicals: a natural reservoir for the green synthesis of gold and silver nanoparticles 

      Park, Y.; Hong, Y. N.; Weyers, A.; Kim, Y. S.; Linhardt, R. J. (2011-09-01)
      Currently, sustainability initiatives that use green chemistry to improve and/or protect our global environment are becoming focal issues in many fields of research. Instead of using toxic chemicals for the reduction and ...

    • Polysulfated Carbohydrates Analyzed as Ion-Paired Complexes with Basic Peptides and Proteins Using Electrospray Negative Ionization Mass Spectrometry 

      Siegel, Marshall M.; Tabei, Keiko; Kagan, Michael Z.; Vlahov, Ioncho R.; Hileman, Ronald E.; Linhardt, Robert J. (1997-07-01)
      Electrospray ionization mass spectrometry was used in the negative ion mode to analyze complexes of sucrose octasulfate, sucrose heptasulfate and sulfated alpha-, beta- and gamma-cyclodextrins with synthetically prepared ...

    • Porphyrin-based compounds and their applications in materials and in medicine 

      Shi, Yingyan; Zhang, Fuming; Linhardt, Robert J. (2021-04-01)
      Porphyrin-based compounds has been the subject of recent investigations for their chemical and biological properties. A variety of chemical modifications have been introduced in the porphyrin skeleton to improve the ...

    • Potential anti-SARS-CoV-2 activity of pentosan polysulfate and mucopolysaccharide polysulfate 

      Zhang, Fuming; He, Peng; Rodrigues, Andre L.; Jeske, Walter; Tandon, Ritesh; Bates, John T.; Bierdeman, Michael A.; Fareed, Jawed; Dordick, Jonathan; Linhardt, Robert J. (Multidisciplinary Digital Publishing Institute (MDPI), 2022-02-01)
      With the increased prevalence of new SARS-CoV-2 variants of concern, such as Delta and Omicron, the COVID-19 pandemic has become an ongoing human health disaster, killing millions worldwide. SARS-CoV-2 invades its host ...

    • Preparation and Anticoagulant Activity of Fully O-SulfonatedGlycosaminoglycans 

      Toida, T.; Maruyama, T.; Ogita, Y.; Suzuki, A.; Toyoda,; Imanari, H.T.; Linhardt, Robert J. (1999)
      Glycosaminoglycans including dermatan sulphate, hyaluronan, heparan sulphate and heparin were chemically modified by O-sulphonation. By altering the reaction conditions, products having a different degree of O-sulphonation ...

    • Preparation and anticoagulant activity of phosphosulfomannan PI-88 

      Yu, Guangli; Gunay, Nur Sibel; Linhardt, Robert J.; Toida, Toshihiko; Fareed, Jawed; Hoppensteadt, Debra A.; Shadid, Hazar; Ferro, Vito; Li, Caiping; Fewings, Kym; Palermo, Maria C.; Podger, Denis (2002-10-01)
      A yeast-derived phosphomannan mixture was chemically sulfonated and the composition and structure of the product mixture was studied. This phosphosulfomannan mixture, PI-88, is currently under clinical evaluation as an ...

    • Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides 

      Cai, Chao; Edgar, Kristi; Liu, Jian; Linhardt, Robert J. (Elsevier, 2013-05-03)
      A 'clickable' disaccharide was prepared by treating the aldehyde precursor with hydroxylamine, followed by the catalytic hydrogenation and diazotransfer reaction. This disaccharide was successfully applied to the elongation ...

    • Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives 

      Nadkarni, V.D.; Toida, T.; VanGorp, C.L.; Schubert, R.L.; Weiler, J.M.; Hansen, K.P.; Caldwell, E.E.O.; Linhardt, Robert J. (1996)
      Chondroitin and dermatan sulfates are families of structurally complex, sulfated, linear polysaccharides called glycosaminoglycans (GAGs) with alternating uronic acid and N-acetylated D-galactosamine residues [ 1] (Scheme ...

    • Preparation and Isolation of Neoglycoconjugates Using Biotin-StreptavidinComplexes 

      Kuberan, B.; Gunay, N.S.; Dordick, J.S.; Linhardt, Robert J. (1999)
      Glycoproteins commercially available in multi-gram quantities, were used to prepare milligram amounts of neoglycoproteins. The glycoproteins bromelain and bovine gamma-globulin were proteolyzed to obtain glycopeptides or ...

    • Preparation and Structural Characterization of Large Heparin-Derived Oligosaccharides 

      Pervin, Azra; Gallo, Cindy; Jandik, Kenneth A.; Han, Xue Jun; Linhardt, Robert J. (1995-02-01)
      Porcine mucosal heparin was partially depolymerized with heparin lyase I and then fractionated into low-molecular-weight (< 5000) and high-molecular-weight (> 5000) oligosaccharides by pressure filtration. The high-molec ...

    • Preparation and Structural Determination of Dermatan Sulfate-Derived Oligosaccharides 

      Yang, Hyun Ok; Gunay, Nur Sibel; Toida, Toshihiko; Kuberan, Balagurunathan; Yu, Guangli; Kim, Yeong Shik; Linhardt, Robert J. (2000-01-01)
      Eight oligosaccharides were prepared from dermatan sulfate (DS) and their structures were elucidated. Porcine intestinal mucosal DS was subjected to controlled depolymerization using chondroitin ABC lyase (chondroitinase ...

    • Preparation and Structural Determination of Large Oligosaccharides Derived from Acharan Sulfate 

      Chi, Lianli; Munoz, Eva M.; Choi, Hyung Seok; Ha, Young Wan; Kim, Yeong Shik; Toida, Toshihiko; Linhardt, Robert J. (Elsevier, 2006-05-22)
      The structures of a series of large oligosaccharides derived from acharan sulfate were characterized. Acharan sulfate is an unusual glycosaminoglycan isolated from the giant African snail, Achatina fulica. Oligosaccharides ...