Browsing The Linhardt Research Labs by Title
Now showing items 757-776 of 1022
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Preparation of synthetic wood composites using ionic liquids
(2011-11-01)Synthetic wood composite films containing cellulose, hemicelluloses, and lignin, the three major components of natural wood, were prepared in a room temperature ionic liquid solvent, 1-ethyl-3-methylimidazolium acetate, ... -
Pretreatment Procedure for the Microdetermination of Chondroitin Sulfate in Plasma and Urine
(2002-03-15)A new, simple, and rapid pretreatment method for the determination of chondroitin sulfate, dermatan sulfate, and hyaluronan from urine and blood plasma samples has been developed. Plasma proteins were first converted into ... -
Previews: Heparin-Induced Cancer Cell Death
(2004)Heparin uptake into cancer cells can be promoted by conjugation to poly (β-amino ester)s. Internalized heparin is cytotoxic, causing cancer cell death by interfering with transcription factor activity and inducing apoptosis, ... -
Probing Aβ interactions with synthetic heparan sulfate oligosaccharides
(2021)Heparan sulfate (HS) can play important roles in the biology and pathology of amyloid β (Aβ), a hallmark of Alzheimer's disease. To better understand the structure-activity relationship of HS/Aβ interactions, synthetic HS ... -
Probing the Interaction of Dengue Virus Envelope Protein with Heparin: Assessment of Glycosaminoglycan-Derived Inhibitors
(2001-06-21)A structure-activity relationship study was carried out to facilitate development of inhibitors of dengue virus infectivity. Previous studies demonstrated that a highly charged heparan sulfate, a heparin-like glycosaminoglycan ... -
Production and characterization of recombinant collagen binding resilin nanocomposite for regenerative medicine applications
(2019-12-01)Development of mechanically stable and multifunctional biomaterials for sensing, repair, and regeneration applications is of great importance. Herein, we investigate the potential of recombinant resilin-like (Res) nanocomposite ... -
Production and Chemical Processing of Low Molecular Weight Heparins
(1999)Heparin is an animal tissue extract that is widely used as an anticoagulant drug. A number of low molecular weight heparins (LMWHs), introduced in the past decade, are beginning to displace pharmaceutical (or compendial) ... -
Production of a low molecular weight heparin using recombinant unsaturated glycuronidase
(2015)The Δ4,5 unsaturated uronate (4-deoxy-α-l-threo-hex-4-eno-pyranosyluronic acid) residue is produced through the depolymerization of heparin, heparosan, and heparan sulfate with heparin lyases. The recovery of unsaturated ... -
Production of chondroitin in metabolically engineered E. coli
(2015-01-01)Chondroitin sulfates, widely used in the treatment of arthritis, are glycosaminoglycans extracted from food animal tissues. As part of our ongoing efforts to separate the food chain from the drug chain, we are examining ... -
Production of deuterated cyanidin 3-O-glucoside from recombinant Escherichia coli
(American Chemical Society (ACS), 2018-09-30)Anthocyanins are plant secondary metabolites that, despite their chemical instability, have found many applications as natural food colorants. They are also known for their beneficial health effects because of their ... -
Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two Dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry
(2015-09-01)Low molecular weight heparins (LMWHs) are polydisperse and microheterogenous mixtures of polysaccharides used as anticoagulant drugs. Profiling analysis is important for obtaining deeper insights into the structure of ... -
Profiling pneumococcal type 3-derived oligosaccharides by high resolution liquid chromatography-tandem mass spectrometry
(Elsevier, 2015-06-05)Pneumococcal type-3 polysaccharide (Pn3P) is considered a major target for the development of a human vaccine to protect against Streptococcus pneumoniae infection. Thus, it is critical to develop methods for the preparation ... -
Programming designer DNA nanostructures for inhibition of virus infection
(2022)The challenges underlying current coronavirus disease 2019 treatment and rapid diagnostic development are already well known from previous encounters with newly emerging pathogens (e.g., the 2009 H1N1 pandemic 1,2). ... -
Proline to Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis Syndromes Through the Enhancement of FGF Binding Affinity
(2004)Identical proline-->arginine gain-of-function mutations in fibroblast growth factor receptor (FGFR) 1 (Pro252Arg), FGFR2 (Pro253Arg) and FGFR3 (Pro250Arg), result in type I Pfeiffer, Apert and Muenke craniosynostosis ... -
Prolonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8
(2021-07-31)Natural active polysaccharides are attracting increased attention from pharmaceutical industries for their valuable biological activities. However, the application of polysaccharides has been restricted due to their ... -
Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
(Nature, 2020-12-01)The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by both the normal microbiota and enteric pathogens. Some members of the microbiota utilise mucin glycoproteins as a nutrient ... -
Properties of Carbohydrates
(2001)The physical, chemical, and biological properties of carbohydrates depend on their primary structures and, less frequently, on their higher-order structures. While monosaccharides are comprised of a single saccharide unit, ... -
Protective effects of six different pectic polysaccharides on DSS-induced IBD in mice
(2022-06-01)Administration of pectic polysaccharides is a therapeutic strategy in the management of gut inflammation. However, the knowledge about the effects of different dietary sources and structure are missing. This study explored ... -
Protein-associated water effects the removal of blood proteins from metallic substrates
(2011-03-01)Removing adsorbed protein from metals has significant health and industrial consequences. There are numerous protein-adsorption studies using model self-assembled monolayers or polymeric substrates but hardly any high-resolution ... -
Proteoglycan Sequence
(Royal Society of Chemistry, 2012)Proteoglycans (PGs) are among the most structurally complex biomacromolecules in nature. They are present in all animal cells and frequently exert their critical biological functions through interactions with protein ligands ...