Browsing The Linhardt Research Labs by Title
Now showing items 807-826 of 1022
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Recent progress and applications in glycosaminoglycan and heparin research
(Elsevier, 2009-12-01)Heparin, the focus of this review, is a critically important anticoagulant drug produced from animal sources, which was contaminated last year leading to a number of adverse side effects, some resulting in death. Heparin ... -
Recent Progress of Marine Polypeptides as Anticancer Agents
(2018-01-01)Background: Marine environment constitutes an almost infinite resource for novel anticancer drug discovery. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer ... -
Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide
(2016-09-01)Heparosan, the capsular polysaccharide of Escherichia coli K5 having a carbohydrate backbone similar to that of heparin, has become a potential precursor for bioengineering heparin. In the heparosan biosynthesis pathway, ... -
Reconsidering conventional and innovative methods for pectin extraction from fruit and vegetable waste: Targeting rhamnogalacturonan I
(Elsevier, 2019-12-01)Background: Rhamnogalacturonan I (RG-I) is composed of a backbone of repeating disaccharide units →2)-α-L-Rhap-(1 → 4)-α-D-GalpA-(1→ with neutral sugar sidechains consisting of arabinose and galactose with variable linking ... -
Recovery of high value-added nutrients from fruit and vegetable industrial wastewater
(2019-09-01)The industrial processing water of fruit and vegetables has raised serious environmental concerns due to the presence of many important bioactive compounds being disposed in the wastewater. Bioactive compounds have great ... -
Red algal sulfated galactan binds and protects neural cells from HIV-1 gp120 and Tat
(2021-08-01)The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), ... -
Regio and Stereoselective Synthesis of Derivatives of L-Idopyranuronic Acid and D-Glucopyranuronic Acid from D4-Uronates
(1997)The stereoselective synthesis of β-d-glucopyranosiduronic, α-l-idopyranosiduronic, and α-l-altropyranosiduronic acids has been performed from different Δ4-uronate monosaccharides. Bromination of the C-4,5 double bond ... -
Regio- and Stereoselective Synthesis of b-D-Gluco-, a -L-Ido-and a -L-Altro pyranosiduronicAcids from D 4-Uronates
(1999)The stereoselective synthesis of B-D-glucopyranosiduronic, R-L-idopyranosiduronic, and R-L-altro-pyranosiduronic acids has been performed from different ∆4-uronate monosaccharides. Bromination of the C-4,5 double bond ... -
Regioselective Synthesis of Derivatives of L-Idopyranuronic Acid: A Key Constituent of Glycosaminoglycans
(1995-11-13)Synthesis of new and potentially universal l-idopyranuronic glycosyl-donor and/or -acceptor 13 was performed starting from d-glucofuranurono-6,3-lactone 1. After simple C-5-epimerization, C-1thioacetalization and regioselective ... -
Regioselective Synthesis of L-Idopyranuronic Acid Derivatives:Intermolecular Aglycone Transfer Under Standard Glycosylation Conditions
(1997)C-1-thioacetalization of L-idofuranurono-6,3-lactone followed by regioselective p-methoxybenzylidenation at C-2 and C-4 gave the hydroxylactones 4 and 19, which were protected at C-5 with TBDMS. Lactone ring opening with ... -
Regioselective Synthesis of Sucrose Monoesters as Surfactants
(1997-01-01)A highly regioselective conversion of sucrose into 6-O-acyl derivatives is reported. First sucrose was transformed into the dibutyltin acetal, thus enhancing the nucleophilicity at the C-6 oxygen and restricting the ... -
Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products
(2015-05-01)Malonyl-CoA is the building block for fatty acid biosynthesis and also a precursor to various pharmaceutically and industrially valuable molecules, such as polyketides and biopolymers. However, intracellular malonyl-CoA ... -
Regulation Activity of Heparin in Complement System
(2005)Heparin (HP) can bind to a variety of proteins, including growth factors, pro-inflammatory chemokines and cytokines, extracellular matrix proteins, and complement proteins. HP has a variety of biological activities, many ... -
Regulation of PTP1B activation through disruption of redox-complex formation
(Nature, 2020-02-01)We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ ... -
Release and Preparation of Intact and Unreduced N-linkedOligosaccharides from Sf-9 Insect Cells
(1999)Glycosylation, the addition of carbohydrates to a peptide backbone, is the most extensive cotranslational and posttranslational modification made to proteins by eukaryotic cells. The glycosylation profile of a recombinant ... -
Remodeling of Glycosaminoglycans During Differentiation of Adult Human Bone Mesenchymal Stromal Cells toward Hepatocytes
(2019-02-15)There is a critical need to generate functional hepatocytes to aid in liver repair and regeneration upon availability of a renewable, and potentially personalized, source of human hepatocytes (hHEP). Currently, the vast ... -
Repurposing paper by-product lignosulfonate as sulfur donor/acceptor for high performance lithium-sulfur batteries
(2018-01-01)The recovery and repurposing of biomass are critically important and make a significant contribution to environmental preservation. Lignosulfonate, a by-product of the paper manufacturing industry, is an abundant low cost ... -
Resistance of Heparinase-Derived Heparin Fragments to Biotransformation
(Elsevier, 1989)The biotransformation of heparinase-derived heparin fragments was examined via a combined approach using 35S-labeled heparin fragments as well as unlabeled chemically defined heparin fragments. Rats dosed with either ... -
Resolution of Structurally Similar Glycoproteins by Affinity-BasedReversed Micellar Extraction and Separation
(1998)Affinity-based reversed micellar extraction and separation (ARMES) has proven effective in separating glycoproteins from nonglycosylated proteins from natural sources. The ability of ARMES to resolve closely related ... -
Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin
(Elsevier, 2011-12-10)The chemical step in the chemoenzymatic synthesis of bioengineered heparin has been examined and optimized statistically using a response surface methodology. A four factor, two level full factorial design experiment and ...