Browsing The Linhardt Research Labs by Title
Now showing items 951-970 of 1022
-
Synthesis of Gold and Silver Nanoparticles Stabilized with Glycosaminoglycans having Distinctive Biological Activities
(American Chemical Society (ACS), 2009-03-09)Metal nanoparticles have been studied for their anticoagulant and anti-inflammatory efficacy in various models. Specifically, gold and silver nanoparticles exhibit properties that make these ideal candidates for biological ... -
Synthesis of heparin immobilized-magnetically addressable cellulose nanofibers for biomedical applications
(2016-11-14)Magnetically responsive heparin-immobilized cellulose nanofiber composites were synthesized by wet-wet electrospinning from a nonvolatile, room-temperature ionic liquid (RTIL), 1-methyl-3-methylimidazolium acetate ([EMIM][Ac]), ... -
Synthesis of nor-C-linked neuraminic acid disaccharide: A versatile precursor of C-analogs of oligosialic acids and gangliosides
(American Chemical Society (ACS), 2007-04-13)The Neu5Acalpha(2,8)Neu5Ac disaccharide is an important constituent of tumor related antigen, however, the O-linkage is catabolically unstable. Vaccination with a catabolically stable sialic acid C-glycoside analog might ... -
Synthesis of Saponins Using Partially Protected Glycosyl Donors
(2003)A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and ... -
Synthesis of selected unnatural sugar nucleotides for biotechnological applications
(Taylor and Francis, 2021-01-01)Sugar nucleotides are the principal building blocks for the synthesis of most complex carbohydrates and are crucial intermediates in carbohydrate metabolism. Uridine diphosphate (UDP) monosaccharides are among the most ... -
Synthesis of Serine-Based Neuraminic Acid C-Glycoside
(2003-04-04)Cell-surface carbohydrates are classified by the nature of their linkages to the protein as either N-linked or O-linked. O- and N-glycans are involved in a number of important biological functions. These activities can be ... -
Synthesis of Silica – Gold Nanocomposites and their Porous Nanoparticles by In – Situ Approach
(2006-10-10)We demonstrate the one-step synthesis of a silica-gold nanocomposite by simultaneous hydrolysis and reduction of gold chloride. The aminophenyl group was used as a reducing agent, and the trimethoxy silane group acts a ... -
Synthesis of Sucrose-Based Surfactants Through Regioselective Sulfonation of Acylsucrose and the Nucleophilic Opening of a Sucrose Cyclic Sulfate
(1998-05-01)Synthesis of a new class of anionic and amphoteric sucrose-based surfactants is described. Direct sulfonation of 6-O-acylsucrose using the pyridine–sulfur trioxide complex led to a mixture of the regioisomeric monosulfates, ... -
Synthesis of Sulfosucrose Derivatives for Evaluation as Regulators of Fibroblast Growth Factor Activity
(2002-11-04)Based on X-ray crystallographic studies on sucrose octasulfate in complex with fibroblast growth factor and its receptor, three analogs of sucrose octasulfate were regioselectively synthesized for biological evaluation as ... -
Synthesis of the Bis-Tetrahydropyrano[2,3-b:2’,3’-e] Piperazine Ring System: A New Tricyclic Heterocycle from D-Glucosamine
(1996-01-01)2-Amino-3,4,6-tri-O-benzyl-2-deoxy-D-glucopyranose was transformed into its bis(tetrahydropyranyl)piperazine dimer (4) by reaction with 1,1′-thionyldiimidazole or 1,1′-sulfonyldiimidazole. This dimeric form of glucosamine ... -
Synthesis of Tin (II) Phosphate Open Frameworks Using Isomers of 1, 2-Diaminocyclohexane as Template
(2007)A novel layered framework of tin(II) phosphate, [Sn4(PO4)3(OH)]2–·[trans-1,2-C6H10(NH3)2]2+, has been synthesized under hydrothermal conditions with tin(II) oxalate, phosphoric acid and a mixture of trans- and cis-1,2-di ... -
Synthesis of Uridine 5’-Diphosphoiduronic Acid: A Potential Substrate for the Chemoenzymatic Synthesis of Heparin
(American Chemical Society (ACS), 2008-10-03)An improved understanding of the biological activities of heparin requires structurally defined heparin oligosaccharides. The chemoenzymatic synthesis of heparin oligosaccharides relies on glycosyltransferases that use ... -
Synthesis, structural, and biological studies on a pseudodisaccharide containing a bicyclic, bridged carba-sugar
(2011-07-15)Two carba-sugar containing pseudodisaccharide diastereomers have been synthesized from a racemic bicyclooctene derivative. The determination of the absolute configurations was carried out by means of CD measurements, CD ... -
Synthetic and Natural Polysaccharides with Anticoagulant Properties
(2004)Anticoagulant polysaccharides have been of interest to the medical profession since discovery of heparin by McLean in 1916 [1]. Since that time considerable research has been directed at improving anticoagulant and ... -
Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis
(2021-03-16)Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis -
Synthetic heparin
(Elsevier, 2012)Heparin is a complex polysaccharide-based anticoagulant drug that is essential for the practice of modern medicine. Used in extracorporeal therapies, such as kidney dialysis, in the treatment of coagulation disorders, such ... -
Synthetic Oligosaccharide Stimulates and Stabilizes Angiogenesis: Structure-Function Relationships and Potential Mechanisms
(Wolters Kluwer, 2006-08-01)To determine the proangiogenesis effect of series of saccharides and a synthetic oligosaccharide and potential mechanisms, an in vitro 3-dimensional endothelial cell sprouting (3D-ECS) assay and the chick chorioallantoic ... -
Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties
(2003-10-21)Heparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep venous thrombosis. The discovery of an antithrombin binding domain in heparin focused interest ... -
Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins
(American Association for the Advancement of Science (AAAS), 2017-09-06)Low-molecular weight heparin (LMWH) is used clinically to treat clotting disorders. As an animal-sourced product, LMWH is a highly heterogeneous mixture, and its anticoagulant activity is not fully reversible by protamine. ... -
Systematic analysis of enoxaparins from different sources with online one- and two-dimensional chromatography
(2019-06-21)Enoxaparin, one of the most important low-molecular-weight heparins (LMWHs), is widely used as a clinical anticoagulant. Different production processes and animal sources of its precursor (unfractionated heparin) can result ...