Browsing The Linhardt Research Labs by Title
Now showing items 97-116 of 1022
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Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering
(American Chemical Society (ACS), 2017-10-31)Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone ... -
Biodegradable Polymers for the Controlled Delivery of Vaccines
(1994)New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to ... -
Biodegradable Polymers for the Controlled Delivery of Vaccines
(1992)New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to ... -
Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site
(The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2013-12-27)HS3st1 (heparan sulfate 3-O-sulfotransferase isoform-1) is a critical enzyme involved in the biosynthesis of the antithrombin III (AT)-binding site in the biopharmaceutical drug heparin. Heparin is a highly sulfated ... -
Bioengineered Heparins and Heparan Sulfates
(Elsevier, 2016)Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex ... -
Bioengineered production of glycosaminoglycans and their analogues
(2021)Glycosaminoglycans (GAGs) are a class of linear polysaccharides, consisting of alternating disaccharide sequences of uronic acid and hexosamines (or galactose) with and without sulfation. They can interact with various ... -
Bioengineering murine mastocytoma cells to produce anticoagulant heparin
(2014-03-01)Heparin (HP), an important anticoagulant polysaccharide, is produced in a complex biosynthetic pathway in connective tissue-type mast cells. Both the structure and size of HP are critical factors determining the anticoagulation ... -
Bioerodable Polyanhydrides for Controlled Drug Delivery
(1983)Initial in vitro and in vivo (rat) studies using a poly(anhydride), poly[bis(p-carboxyphenoxy)methane], as a bioerodible matrix for controlled drug delivery are described. Drug delivery matrices fabricated from this material ... -
Bioerodible Polyanhydrides For Controlled Drug Delivery
(1983)Initial in vitro and in vivo (rat) studies using a poly(anhydride), poly[bis(p-carboxyphenoxy)methane], as a bioerodible matrix for controlled drug delivery are described. Drug delivery matrices fabricated from this material ... -
Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR
(Elsevier, 2012-01-01)Glycosaminoglycans (GAGs) interact with a number of cytokines and growth factors thereby playing an essential role in the regulation of many physiological processes. These interactions are important for both normal signal ... -
Biotechnology for removal of indoor gaseous formaldehyde
(2020-05-01)Formaldehyde is a ubiquitous carcinogenic indoor pollutant. The treatment of formaldehyde has attracted increasing social attention. Over the past few decades, an increasing number of publications have reported approaches ... -
Blood Deheparinization Using Immobilized Microbial Heparinase
(Canadian Society for Chemical Engineering, 1981)Extracorporeal medical machines (e.g., artificial kidney, pump-oxygenator) perfused with blood have been an effective part of the therapeutic armamentarium for many years. These devices all rely on systemic heparinization ... -
Bolometric properties of semiconducting and metallic single-walled carbon nanotube composite films
(2015-03-18)Single-walled carbon nanotubes (SWNTs) have shown interesting bolometric properties, making them good candidates for the detection of infrared and terahertz radiation. However, little has been reported on the bolometric ... -
Borrelia burgdorferi glycosaminoglycan binding proteins: Potential target of new therapeutics against Lyme disease
(Microbiology Society, 2017-12-01)The spirochete bacterium Borrelia burgdorferi sensu lato is the causative agent of Lyme disease, the most common vector-borne disease in Europe and the United States. The spirochetes can be transmitted to humans via ticks, ... -
Bottom-up analysis using liquid chromatography-Fourier transform mass spectrometry to characterize fucosylated chondroitin sulfates from sea cucumbers
(Oxford University Press, 2019-11-01)Fucosylated chondroitin sulfates (FCSs) from sea cucumbers have repetitive structures that exhibit minor structural differences based on the organism from which they are recovered. A detailed characterization of FCSs and ... -
Bottom-up and top-down profiling of pentosan polysulfate
(Royal Society of Chemistry, 2019-08-21)Pentosan polysulfate (PPS) is a semi-synthetic glycosaminoglycan (GAG) mimetic. PPS, synthesized through the chemical sulfonation of a plant-derived β-(1 → 4)-xylan, is the active pharmaceutical ingredient of the drug ... -
Bottom-up LMWH analysis using LC-FTMS for extensive characterization
(American Chemical Society (ACS), 2014)Low molecular weight heparins (LMWHs) are heterogeneous, polydisperse, and highly negatively charged mixtures of glycosaminoglycan chains prescribed as anticoagulants. The detailed characterization of LMWH is important for ... -
Breast cyst fluid heparan sulfate is distinctively n-sulfated depending on apocrine or flattened type
(2015)Breast cyst fluid (BCF) contained in gross cists is involved with its many biomolecules in different stages of breast cystic development. Type I apocrine and type II flattened cysts are classified based on biochemical, ... -
B’reshith
(2018-09-10)The Hebrew word "b'reshith" (בְּרֵאשִׁית) means "in the beginning". It is the first word and title of the Book of Genesis, and it describes a process of creation. The four authors were present at the beginning of Langer ...