Browsing The Linhardt Research Labs by Title
Now showing items 249-268 of 1022
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Decline in arylsulfatase B (N-acetylgalactosamine-4-sulfatase) leads to increased EGFR expression due to SHP2 inhibition and JNK activation in prostate
(The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2018)Epidermal growth factor receptor (EGFR) has a crucial role in cell differentiation and proliferation and cancer, and its expression appears to be up-regulated when arylsulfatase B (ARSB or GalNAc-4-sulfatase) is reduced. ... -
Degradation and Release Properties of Poly (D,L-Lactide-co-Glycolide, 50:50) Pellets Fabricated From Three Commercial Polymers
(1993)Poly(D,L-lactide-co-glycolide, 50:50) samples of similar molecular weight were obtained from three commercial sources and were characterized by gel permeation chromatography, differential scanning calorimetry, X-ray powder ... -
Degradation of Chondroitin Sulfate and Dermatan Sulfate with Chondroitin Lyases
(2001-01-01)Glycosaminoglycans (GAGs) are a family of complex linear polysaccharides characterized by a repeating core disaccharide structure typically comprised of an N-substituted hexosamine and an uronic acid residue. They can be ... -
Degradation of Heparan Sulfate with Heparin Lyases
(2001-01-01)Glycosaminoglycan (GAG), heparan sulfate (HS), and heparin are a polydisperse mixture of linear polysaccharides composed of glucosamine residues 1→ 4 linked to uronic acid residues. The major repeating unit in heparin is ... -
Degradation of Poly(Ester) Microspheres
(1990)Biodegradable polymeric microspheres have been prepared by spray drying, precipitation, rotary evaporation and press grinding methods. Erosion of microspheres of poly(lactide), poly(3-hydroxybutyrate), copolymers of lactide ... -
The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells
(Public Library of Science (PLoS), 2021-08-01)Several enveloped viruses, including herpesviruses attach to host cells by initially interacting with cell surface heparan sulfate (HS) proteoglycans followed by specific coreceptor engagement which culminates in virus-host ... -
Dengue Virus Infectivity Depends on Envelope Protein Binding to Target Cell Heparan Sulfate
(1997-08-01)Dengue virus is a human pathogen that has reemerged as an increasingly important public health threat. We found that the cellular receptor utilized by dengue envelope protein to bind to target cells is a highly sulfated ... -
Depolymerized RG-I enriched pectin from citrus segment membrane modulates gut microbiota, increases SCFAs production, promotes the growth of Bifidobacterium spp., Lactobacillus spp. and Faecalibaculum spp
(2019-12-01)Rhamnogalacturonan-I (RG-I)-enriched pectin (WRP) was recovered from citrus processing water by sequential acid and alkaline treatments in a previous study. RG-I-enriched pectin was proposed as a potential supplement for ... -
Dermatan Sulfate as a Potential Therapeutic Agent
(1995-01-01)Dermatan sulfate is a linear, sulfated polysaccharide and is a glycosaminoglycan component of several important proteoglycans. This minireview discusses the biosynthesis, structure and biological function of dermatan sulfate ... -
Design and synthesis of unnatural heparosan and chondroitin building blocks
(2011-05-06)Triazole linked heparosan and chondroitin disaccharide and tetrasaccharide building blocks were synthesized in a stereoselective manner by applying a very efficient copper catalyzed azide−alkyne cycloaddition (CuAAC) ... -
Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure
(American Association for the Advancement of Science (AAAS), 2020-03-18)Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute liver failure (ALF) in the United States and Europe. The progression of the disease is attributed to sterile inflammation induced by the ... -
Design of homogeneous and reversible low molecular weight heparins
(Nature, 2014)Low-molecular-weight heparins (LMWHs) are carbohydrate-based anticoagulants clinically used to treat thrombotic disorders, but impurities, structural heterogeneity or functional irreversibility can limit treatment options. ... -
Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition
(Nature, 2020-01-01)DNA, when folded into nanostructures with a specific shape, is capable of spacing and arranging binding sites into a complex geometric pattern with nanometre precision. Here we demonstrate a designer DNA nanostructure that ... -
Detection of cerebrospinal fluid leakage by specific measurement of transferrin glycoforms
(2015-10-01)A simple and rapid detection of cerebrospinal fluid (CSF) leakage would benefit spine surgeons making critical postoperative decisions on patient care. We have assessed novel approaches to selectively determine CSF ... -
Detection of Glycosaminoglycans as a Copper (II) Complex in Capillary Electrophoresis
(1996)Glycosaminoglycans including heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate and hyaluronic acid were analyzed by reversed polarity capillary electrophoresis. Detection was achieved at 240 nm based on the ... -
Detection of Glycosaminoglycans as a Copper (II) Complex in HPLC
(1997)Glycosaminoglycans including heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate and hyaluronan were analyzed by high-performance gel filtration chromatography. Detection was achieved at 240 nm based on the ... -
Detection of glycosaminoglycans by polyacrylamide gel electrophoresis and silver staining
(Jove, 2021-02-01)Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) and chondroitin sulfate (CS) are ubiquitous in living organisms and play a critical role in a variety of basic biological structures and processes. As polymers, ... -
Detection of Protamine Using a Promising Metal Organic Frameworks Based Fluorescent 1 Molecular Device BZA-BOD@ZIF-90
(2021)Herein, we designed a BODIPY-based probe ([email protected]) with good stability through the encapsulation of metal-organic frameworks (MOFs). [email protected] can selectively detect protamine based on an aggregation-induced ... -
Determination of cerebrospinal fluid leakage by selective deletion of transferrin glycoform using an immunochromatographic assay
(Ivyspring International, 2019-01-01)Cerebrospinal fluid (CSF) leakage can lead to brain and spine pathologies and there is an urgent need for a rapid diagnostic method for determining CSF leakage. Beta-2 transferrin (β2TF), asialotransferrin, is a specific ... -
Determination of the Composition of the Oligosaccharide Phosphate Fraction of Pichia holstii NRRL Y-2448 Phosphomannan by Capillary Electrophoresis and HPLC
(2002-01-01)The promising new anticancer agent, PI-88, is prepared by the sulfonation of the oligosaccharide phosphate fraction of the extracellular phosphomannan produced by the yeast Pichia (Hansenula) holstii NRRL Y-2448. The ...