Browsing The Linhardt Research Labs by Title
Now showing items 389-408 of 1022
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Fabrication of homotypic neural ribbons as a multiplex platform optimized for spinal cord delivery
(Nature, 2020-12-01)Cell therapy for the injured spinal cord will rely on combined advances in human stem cell technologies and delivery strategies. Here we encapsulate homotypic spinal cord neural stem cells (scNSCs) in an alginate-based ... -
Facile pretreatment of lignocellulosic biomass at high loadings in room temperature ionic liquids
(2011-12-01)Ionic liquids (ILs) have emerged as attractive solvents for lignocellulosic biomass pretreatment in the production of biofuels and chemical feedstocks. However, the high cost of ILs is a key deterrent to their practical ... -
Facile Synthesis of (±)-Paeonilide
(American Chemical Society (ACS), 2007)(+/-)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of ... -
Facile Synthesis of Saponins Containing 2,3-Branched Oligosaccharides by Using Partially Protected Glycosyl Donors
(American Chemical Society (ACS), 2004-08-06)Two natural saponins 1 and 2, isolated from Solanum indicum L., and containing 2,3-branched sugar moieties, have been efficiently synthesized. Partially protected monosaccharide and disaccharide donors were used to facilitate ... -
Factors released from endothelial cells exposed to flow impact adhesion, proliferation, and fate choice in the adult NSC lineage
(2017)The microvasculature within the neural stem cell (NSC) niche promotes self-renewal and regulates lineage progression. Previous work identified endothelial-produced soluble factors as key regulators of neural progenitor ... -
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling
(Springer Nature, 2020-07-14)Background: The formation of supernumerary teeth is an excellent model for studying the molecular mechanisms that control stem/progenitor cell homeostasis needed to generate a renewable source of replacement cells and ... -
Fast preparation of RG-I enriched ultra-low molecular weight pectin by an ultrasound accelerated Fenton process
(Nature, 2017-12-01)Pectin, a natural polysaccharide found in the cell wall of most higher plant such as citrus, has drawn much attention due to its potential beneficial role in facilitating the treatment of many diseases like cancer, hyper ... -
Fast preparation of rhamnogalacturonan I enriched low molecular weight pectic polysaccharide by ultrasonically accelerated metal-free Fenton reaction
(2019-10-01)The recovery of pectic polysaccharides with high rhamnogalacturonan I (RG-I) branches from citrus canning processing water was achieved in a previous study aimed at reducing chemical oxygen demand and benefiting both process ... -
Fermented cassava residue lignin prepared by sequential acid steam-explosion and hot-alkaline treatment and its antioxidant properties
(2020-11-01)Fermented cassava residue (FCR) is a solid waste generated in cassava-based ethanol production that constitutes a major environmental challenge and wastes a natural resource. In the present study, a process involving ... -
FGF-FGFR signaling mediated through glycosaminoglycans in microtiter plate and cell-based microarray platforms
(2013-12-17)Fibroblast growth factor (FGF) signals cell growth through its interaction with a fibroblast growth factor receptor (FGFR) and a glycosaminoglycn (GAG) coreceptor. Here, we examine the signaling of five different FGFs (1, ... -
Fibroblast growth factor signaling mediates pulmonary endothelial glycocalyx reconstitution
(2017-06-01)The endothelial glycocalyx is a heparan sulfate (HS)-rich endovascular structure critical to endothelial function. Accordingly, endothelial glycocalyx degradation during sepsis contributes to tissue edema and organ injury. ... -
Fibroblast growth factor-based signaling through synthetic heparan sulfate block copolymers studied using high-cell density 3D cell printing
(The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2014)Four well-defined heparan sulfate (HS) block copolymers containing S-domains (high sulfo group content) placed adjacent to N-domains (low sulfo group content) were chemoenzymatically synthesized and characterized. The ... -
Filter-entrapment enrichment pull-down assay for glycosaminoglycan structural characterization and protein interaction
(Elsevier, 2020-10-01)Heparins are the most pharmaceutically important polysaccharides. These heparin-based anticoagulant/antithrombotic agents include unfractionated heparins, low molecular weight heparins (LMWHs) and ultralow molecular weight ... -
Flexible electrospun cellulose fibers as an affinity packing material for the separation of bovine serum albumin
(2011)Flexible, well-dispersed and continuous 100-nm diameter cellulose fibers were prepared from an ionic liquid solvent by a novel dry-jet wet-electrospinning process. The ribbon fibers formed were chemically activated and an ... -
Flexible Nanocomposite Thin Film Energy Storage Devices
(2007)There is strong recent interest in ultrathin, flexible, safe energy storage devices to meet the various design and power needs of modern gadgets. To build such fully flexible and robust electrochemical devices, multiple ... -
Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides
(American Chemical Society (ACS), 2014-04-18)Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides -
Fractionation of Heparin-Derived Oligosaccharides by Gradient Polyacrylamide-Gel Electrophoresis
(1987-01-01)Heparin-derived oligosaccharides, prepared by using flavobacterial heparinase, having a high degree of heterogeneity (sequence variability) were resolved into sharp well-defined bands by using polyacrylamide gel electrophoresis ... -
Fractionation of sulfated galactan from the red alga Botryocladia occidentalis separates its anticoagulant and anti-SARS-CoV-2 properties
(Elsevier, 2022-05-01)Sulfation pattern and molecular weight (MW) play a key role in the biological actions of sulfated glycans. Besides anticoagulant effects, certain sulfated glycans can also exhibit anti-SARS-CoV-2 properties. To develop a ... -
Fucosylated chondroitin sulfate 9-18 oligomers exhibit molecular size-independent potent antithrombotic activity during circulating in the blood
(2020)Fucosylated chondroitin sulfate (FCS) oligosaccharides extracted from sea cucumber and depolymerized exhibit potent anticoagulant activity. Knowledge of the antithrombotic activity of different size oligosaccharides and ... -
Fucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet
(2019-03-01)Fucosylated chondroitin sulfate from Isostichopus badionotus (fCS-Ib) is a kind of sulfated polysaccharides with well-repeated structure. In our former publications, fCS-Ib has been reported to be a functional food ingredient ...