Browsing The Linhardt Research Labs by Issue Date
Now showing items 41-60 of 1022
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Cultivation of fractionated cells from a bioactive-alkaloid-bearing marine sponge Axinella sp
(2021-05-01)Sponges are among the most primitive multicellular organisms and well-known as a major source of marine natural products. Cultivation of sponge cells has long been an attractive topic due to the prominent evolutionary and ... -
Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides
(2021-04-15)Glycans and glycoconjugates in nature include macromolecules with important biological activities and widely distributed in all living organisms. These oligosaccharides and polysaccharides play important roles in a variety ... -
Glycolipid-containing nanoparticle vaccine engages invariant NKT cells to enhance humoral protection against systemic bacterial infection but abrogates T-independent vaccine responses
(2021-04-15)CD4+ T cells enable the critical B cell humoral immune protection afforded by most effective vaccines. We and others have recently identified an alternative source of help for B cells in mice, invariant NK T (iNKT) cells. ... -
Porphyrin-based compounds and their applications in materials and in medicine
(2021-04-01)Porphyrin-based compounds has been the subject of recent investigations for their chemical and biological properties. A variety of chemical modifications have been introduced in the porphyrin skeleton to improve the ... -
Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis
(2021-03-16)Synthetic heparan sulfate standards and machine learning facilitate the development of solid-state nanopore analysis -
Extraction temperature is a decisive factor for the properties of a pectin
(2021-03-01)Pectin is an important food thickener and gelling agent and also, based on its bioactivities, is becoming viewed as a healthy polysaccharide. The functional properties of pectin are related to its structure which, if raw ... -
Additional role of nicotinic acid hydroxylase for the transformation of 3-succinoyl-pyridine by Pseudomonas sp. JY-Q
(2021-03-01)Nicotine and nicotinic acid (NA) are both considered to be representatives of N-heterocyclic aromatic compounds, and their degradation pathways have been revealed in Pseudomonas species. However, the cooccurrence of these ... -
Construction of heparan sulfate microarray for investigating the binding of specific saccharide sequences to proteins
(2021-03-01)Heparan sulfate (HS) is a heterogeneous, extracellular glycan that interacts with proteins and other molecules affecting many biological processes. The specific binding motifs of HS interactions are of interest, but have ... -
The effect of electrospun scaffolds on the glycosaminoglycan profile of differentiating neural stem cells
(Elsevier, 2021-03-01)The use of electrospun scaffolds for neural tissue engineering applications allows a closer mimicry of the native tissue extracellular matrix (ECM), important for the transplantation of cells in vivo. Moreover, the role ... -
Characterization of Glycosaminoglycan Disaccharide Composition in Astrocyte Primary Cultures and the Cortex of Neonatal Rats
(Springer, 2021-03-01)Astrocytes are major producers of the extracellular matrix (ECM), which is involved in the plasticity of the developing brain. In utero alcohol exposure alters neuronal plasticity. Glycosaminoglycans (GAGs) are a family ... -
Enhanced mandrel design for electrospinning aligned fiber mats from low volatility solvents
(2021-03-01)A cylindrical mandrel with axially aligned rods was designed and tested for the collection of electrospun fibers. Blended polyaniline/polyethylene oxide fibers were electrospun from a solution containing a nonvolatile ... -
Heparosan Chain Characterization: Sequential Depolymerization of E. coli K5 Heparosan by a Bacterial Eliminase Heparin Lyase III and a Bacterial Hydrolase Heparanase Bp to Prepare Defined Oligomers,
(2021-03-01)Heparosan is a non-sulfated polysaccharide and potential applications include, chemoenzymatic synthesis of heparin and heparan sulfates. Heparosan is produced using microbial cells (natural producers or engineered cells). ... -
Preparation of low molecular weight heparin from a remodeled bovine intestinal heparin
(2021-02-25)Bovine intestinal heparins are structurally distinct from porcine intestinal heparins and exhibit lower specific anticoagulant activity (units/mg). The reduced content of N-sulfo, 3-O-sulfo glucosamine, the central and ... -
Structural and immunological studies on the polysaccharide from spores of a medicinal entomogenous fungus Paecilomyces cicadae
(2021-02-15)A neutral branched heteropolysaccharide (Pc0−1) was purified from the spores of Paecilomyces cicadae, which parasitized in the bamboo cicada (Platylomia pieli Kato). The structure of Pc0−1 was analyzed by HPLC, IR, methylation ... -
Effect of electrical stimulation conditions on neural stem cells differentiation on cross-linked PEDOT: PSS films
(Frontiers Media SA, 2021-02-12)The ability to culture and differentiate neural stem cells (NSCs) to generate functional neural populations is attracting increasing attention due to its potential to enable cell-therapies to treat neurodegenerative diseases. ... -
Strong reduction of the chain rigidity of hyaluronan by selective binding of Ca2+ ions
(American Chemical Society (ACS), 2021-02-09)The biological functions of natural polyelectrolytes are strongly influenced by the presence of ions, which bind to the polymer chains and thereby modify their properties. Although the biological impact of such modifications ... -
The application of seaweed polysaccharides and their derived products with potential for the treatment of Alzheimer´s disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-04)Neurodegenerative diseases are among the most widespread diseases affecting humans, and the number of patients is only rising. Seaweed polysaccharide extracts show significant neuroprotective and reparative activities. ... -
MAPK/HOG signaling pathway induced stress-responsive damage repair a mechanism for Pichia pastoris to survive from hyperosmotic stress
(2021-02-01)Abstract BACKGROUND MAPK/HOG signaling pathway plays a key role in the response of yeast to external hyperosmotic stress. Over the past few decades, the regulation mechanism for this pathway in the robust yeast, Saccharomyces ... -
Expression and functional identification of two homologous nicotine dehydrogenases, NicA2 and Nox, from Pseudomonas sp. JY-Q
(2021-02-01)Nicotine contamination in tobacco waste effluent (TWE) from tobacco industry is a serious threat to public health and environment. Microbial degradation is an impending approach to remove nicotine and transform it into ... -
Analysis of the glycosaminoglycan chains of proteoglycans
(Sage, 2021-02-01)Glycosaminoglycans (GAGs) are heterogeneous, negatively charged, macromolecules that are found in animal tissues. Based on the form of component sugar, GAGs have been categorized into four different families: heparin/heparan ...