Browsing Linhardt Research Labs Papers by Title
Now showing items 88-107 of 1022
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Bacteriophage T7 transcription system: an enabling tool in synthetic biology
(2018-12-01)Since its discovery in the 1970s, the T7 RNA polymerase (T7 RNAP) transcription system has been applied extensively as an effective tool in molecular biology because of its robust function in various hosts, including ... -
Benzoate-Based Room Temperature Ionic Liquids – Thermal Properties and Glycosaminoglycan Dissolution
(2006-02-03)Benzoate-based room temperature ionic liquids (RTILs) have been synthesized with cations of varying structures. The thermal properties of these RTILs have been characterized to understand their structure–property relationship. ... -
Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides
(Portland Press, 2012)Heparin and HS (heparan sulfate) exert their wide range of biological activities by interacting with extracellular protein ligands. Among these important protein ligands are various angiogenic growth factors and cytokines. ... -
Binding Between the Integrin aXß2 (CD11c/CD18) and Heparin
(Elsevier, 2007)The interactions between cell surface receptors and sulfated glucosamineglycans serve ubiquitous roles in cell adhesion and receptor signaling. Heparin, a highly sulfated polymer of uronic acids and glucosamine, binds ... -
Biobased diglycidyl ether diphenolates: effect of the ester moiety on fragrance oil microencapsulation by interfacial polymerization
(2022-09-05)Health risks are associated with capsule-forming synthetic chemicals such as formaldehyde, isocyanates, and bisphenol A (BPA). This work is focused on using safe biobased molecules to build capsule walls for oil encapsulation. ... -
Biocatalysts for the Synthesis and Modification of Biopolymers
(1991)Biopolymers are polymers that are biosynthesized from monomeric building blocks. Although biopolymers have been used for many years by the food, pharmaceutical, and specialty chemical industries, they have recently taken ... -
Biocatalytic Synthesis of Sugar-Containing Polyacrylates
(1992)Achemoenzymaticapproachhasbeendevelopedtopreparemonosaccharide-basedpoly-(acrylate)s.ThelipasefromPseudomonascepaciacatalyzedthetransesterificationofavarietyofmonosaccharideswithvinylacrylateinpyridinetogivethe6-acryloyl ... -
Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities in human skeletal disorders
(Oxford, 2004)Gain-of-function missense mutations in FGF receptor 2 (FGFR2) are responsible for a variety of craniosynostosis syndromes including Apert syndrome (AS), Pfeiffer syndrome (PS) and Crouzon syndrome (CS). Unlike the majority ... -
Biochemical strategies for enhancing the in vivo production of natural products with pharmaceutical potential
(2014-02-01)Natural products have been associated with significant health benefits in preventing and treating various chronic human diseases such as cancer, cardiovascular diseases, diabetes, Alzheimer's disease, and pathogenic ... -
Biodegradable and Bioactive Core-Shell Fibers for Tissue Engineering
(American Chemical Society (ACS), 2017-10-31)Poly(glycerol sebacate) (PGS) has increasingly become a desirable biomaterial due to its elastic mechanical properties, biodegradability, and biocompatibility. Here, we report microfibrous core–shell mats of polycaprolactone ... -
Biodegradable Polymers for the Controlled Delivery of Vaccines
(1994)New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to ... -
Biodegradable Polymers for the Controlled Delivery of Vaccines
(1992)New methods for the efficient and effective administration of vaccines are required particularly with the advent of new synthetic subunit vaccines. This chapter describes the approaches of several research groups to ... -
Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin binding site
(The American Society for Biochemistry and Molecular Biology (ASBMB) and Elsevier, 2013-12-27)HS3st1 (heparan sulfate 3-O-sulfotransferase isoform-1) is a critical enzyme involved in the biosynthesis of the antithrombin III (AT)-binding site in the biopharmaceutical drug heparin. Heparin is a highly sulfated ... -
Bioengineered Heparins and Heparan Sulfates
(Elsevier, 2016)Heparin and heparan sulfates are closely related linear anionic polysaccharides, called glycosaminoglycans, which exhibit a number of important biological and pharmacological activities. These polysaccharides, having complex ... -
Bioengineered production of glycosaminoglycans and their analogues
(2021)Glycosaminoglycans (GAGs) are a class of linear polysaccharides, consisting of alternating disaccharide sequences of uronic acid and hexosamines (or galactose) with and without sulfation. They can interact with various ... -
Bioengineering murine mastocytoma cells to produce anticoagulant heparin
(2014-03-01)Heparin (HP), an important anticoagulant polysaccharide, is produced in a complex biosynthetic pathway in connective tissue-type mast cells. Both the structure and size of HP are critical factors determining the anticoagulation ... -
Bioerodable Polyanhydrides for Controlled Drug Delivery
(1983)Initial in vitro and in vivo (rat) studies using a poly(anhydride), poly[bis(p-carboxyphenoxy)methane], as a bioerodible matrix for controlled drug delivery are described. Drug delivery matrices fabricated from this material ... -
Bioerodible Polyanhydrides For Controlled Drug Delivery
(1983)Initial in vitro and in vivo (rat) studies using a poly(anhydride), poly[bis(p-carboxyphenoxy)methane], as a bioerodible matrix for controlled drug delivery are described. Drug delivery matrices fabricated from this material ... -
Biophysical characterization of glycosaminoglycan-IL-7 interactions using SPR
(Elsevier, 2012-01-01)Glycosaminoglycans (GAGs) interact with a number of cytokines and growth factors thereby playing an essential role in the regulation of many physiological processes. These interactions are important for both normal signal ...