Browsing Linhardt Research Labs Papers by Title
Now showing items 797-816 of 1022
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Randomness in the Heparin Polymer: Computer Simulations of Alternative Action Patterns of Heparin Lyase
(1990-01-01)Heparin is a mixture of linear polysaccharides of undetermined sequence. Both biosynthetic data and computer simulation studies have established that each heparin polymer chain is comprised of oligosaccharides of defined ... -
Rapid and accurate determination of the lignin content of lignocellulosic biomass by solid-state NMR
(Elsevier, 2015-02-01)Biofuels and biomaterials, produced from lignocellulosic feedstock, require facile access to cellulose and hemicellulose to be competitive with petroleum processing and sugar-based fermentation. Physical-chemical barriers ... -
Rapid generation of CRISPR/dCas9-regulated, orthogonally repressible hybrid T7-lac promoters for modular, tuneable control of metabolic pathway fluxes in E. coli
(Oxford University Press, 2016)Robust gene circuit construction requires use of promoters exhibiting low crosstalk. Orthogonal promoters have been engineered utilizing an assortment of natural and synthetic transcription factors, but design of large ... -
Rational identification and characterisation of peptide ligands for targeting polysialic acid
(Nature, 2020-12-01)Rational identification and characterisation of peptide ligands for targeting polysialic acid -
Recent advances in biotechnology for heparin and heparan sulfate analysis
(Elsevier, 2020-11-01)Heparan sulfate (HS) is a class of linear, sulfated, anionic polysaccharides, called glycosaminoglycans (GAGs), which present on the mammalian cell surfaces and extracellular matrix. HS GAGs display a wide range of critical ... -
Recent advances in sulfotransferase enzyme activity assays
(2012-06-01)Sulfotransferases are enzymes that catalyze the transfer of sulfo groups from a donor, for example 3′-phosphoadenosine 5′-phosphosulfate, to an acceptor, for example the amino or hydroxyl groups of a small molecule, ... -
Recent Advances in the Synthesis of C-oligosaccharides
(Bentham Science, 2005-12-01)This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, C-oligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the ... -
Recent advances on the one-pot synthesis to assemble size-controlled glycans and glycoconjugates and polysaccharides
(2021-04-15)Glycans and glycoconjugates in nature include macromolecules with important biological activities and widely distributed in all living organisms. These oligosaccharides and polysaccharides play important roles in a variety ... -
Recent Chemical and Enzymatic Approaches to the Synthesis of Glycosaminoglycan Oligosaccharides
(2003-09-29)Glycosaminoglycans, highly charged polycarboxylated, polysulfated polysaccharides, are an important class of therapeutic agents and investigational drug candidates. Heparin has been widely used as a clinical anticoagulant ... -
Recent Progress and Advanced Technology in Carbohydrate-Based Drug Development
(2021-06-01)Carbohydrates, one of the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions, and represent a treasure trove of untapped potential for pharmaceutical applications. ... -
Recent progress and applications in glycosaminoglycan and heparin research
(Elsevier, 2009-12-01)Heparin, the focus of this review, is a critically important anticoagulant drug produced from animal sources, which was contaminated last year leading to a number of adverse side effects, some resulting in death. Heparin ... -
Recent Progress of Marine Polypeptides as Anticancer Agents
(2018-01-01)Background: Marine environment constitutes an almost infinite resource for novel anticancer drug discovery. The biodiversity of marine organisms provides a rich source for the discovery and development of novel anticancer ... -
Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide
(2016-09-01)Heparosan, the capsular polysaccharide of Escherichia coli K5 having a carbohydrate backbone similar to that of heparin, has become a potential precursor for bioengineering heparin. In the heparosan biosynthesis pathway, ... -
Reconsidering conventional and innovative methods for pectin extraction from fruit and vegetable waste: Targeting rhamnogalacturonan I
(Elsevier, 2019-12-01)Background: Rhamnogalacturonan I (RG-I) is composed of a backbone of repeating disaccharide units →2)-α-L-Rhap-(1 → 4)-α-D-GalpA-(1→ with neutral sugar sidechains consisting of arabinose and galactose with variable linking ... -
Recovery of high value-added nutrients from fruit and vegetable industrial wastewater
(2019-09-01)The industrial processing water of fruit and vegetables has raised serious environmental concerns due to the presence of many important bioactive compounds being disposed in the wastewater. Bioactive compounds have great ... -
Red algal sulfated galactan binds and protects neural cells from HIV-1 gp120 and Tat
(2021-08-01)The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), ... -
Regio and Stereoselective Synthesis of Derivatives of L-Idopyranuronic Acid and D-Glucopyranuronic Acid from D4-Uronates
(1997)The stereoselective synthesis of β-d-glucopyranosiduronic, α-l-idopyranosiduronic, and α-l-altropyranosiduronic acids has been performed from different Δ4-uronate monosaccharides. Bromination of the C-4,5 double bond ... -
Regio- and Stereoselective Synthesis of b-D-Gluco-, a -L-Ido-and a -L-Altro pyranosiduronicAcids from D 4-Uronates
(1999)The stereoselective synthesis of B-D-glucopyranosiduronic, R-L-idopyranosiduronic, and R-L-altro-pyranosiduronic acids has been performed from different ∆4-uronate monosaccharides. Bromination of the C-4,5 double bond ... -
Regioselective Synthesis of Derivatives of L-Idopyranuronic Acid: A Key Constituent of Glycosaminoglycans
(1995-11-13)Synthesis of new and potentially universal l-idopyranuronic glycosyl-donor and/or -acceptor 13 was performed starting from d-glucofuranurono-6,3-lactone 1. After simple C-5-epimerization, C-1thioacetalization and regioselective ... -
Regioselective Synthesis of L-Idopyranuronic Acid Derivatives:Intermolecular Aglycone Transfer Under Standard Glycosylation Conditions
(1997)C-1-thioacetalization of L-idofuranurono-6,3-lactone followed by regioselective p-methoxybenzylidenation at C-2 and C-4 gave the hydroxylactones 4 and 19, which were protected at C-5 with TBDMS. Lactone ring opening with ...