Browsing Linhardt Research Labs Papers by Title
Now showing items 68-87 of 1022
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Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone
(1983-01-01)Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant ... -
Annexin V-Heparin Oligosaccharide Complex Suggests Heparan Sulfate-Mediated Assembly on Cell Surfaces
(2001-01-01)Background: Annexin V, an abundant anticoagulant protein, has been proposed to exert its effects by self-assembling into highly ordered arrays on phospholipid membranes to form a protective anti-thrombotic shield at the ... -
Anti-inflammation effects of highly purified low-Mw RG-I pectins on LPS-activated macrophages
(2021-11-01)Pectic oligosaccharides are viewed as excellent immunomodulator, but the specific molecular weight (Mw) range required for anti-inflammatory effects remains unclear. In this study, citrus pectins was depolymerized by the ... -
Anti-metastatic effect of non-anticoagulant low molecular weight heparin versus standard low molecular weight heparin, enoxaparain
(Thieme Medical Publishers, 2006)Low-molecular-weight heparins (LMWH) exhibit potent anticoagulant efficacy via their plasmatic effects on thrombin and factor Xa. These agents are also effective in releasing endothelial tissue factor pathway inhibitor ... -
Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells
(Springer, 2011-08-01)Heparin (HP) inhibits the growth of several cell types in vitro including bovine pulmonary artery (BPA) smooth muscle cells (SMCs). In initial studies we discovered that an O-hexanoylated low-molecular-weight (LMW) HP ... -
Anti-SARS-CoV-2 activity of rhamnan sulfate from Monostroma nitidum
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)The COVID-19 pandemic is a major human health concern. The pathogen responsible for COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades its host through the interaction of its spike (S) protein ... -
Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88
(2001)Heparinomimetic mannopentaose phosphate sulfate (PI-88) (Progen Industries Ltd. Brisbane, Australia), currently developed as an anticoagulant and antiproliferative agent, mainly is composed of a pentomannan. However, ... -
Antimicrobial effects of positively charged, conductive electrospun polymer fibers
(Elsevier, 2020-11-01)In recent years, electrospun polymer fibers have gained attention for various antibacterial applications. In this work, the effect of positively charged polymer fiber mats as antibacterial gauze is studied using electrospun ... -
Antimicrobial mechanism of resveratrol-trans-dihydrodimer produced from peroxidase-mediated oligomerization of resveratrol
(2015)Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of ... -
Antiseptic single wall carbon nanotube bandages
(2009-05-01)Single wall carbon nanotubes (SWCNTs) are coated with polyvinylpyrrolidone-iodine (povidone-iodine or PVPI) in water. This solution of SWCNT and PVPI is deposited as a composite film, composed of individual and bundled ... -
Antithrombin III Binding Site Analysis of Low Molecular Weight Heparin Fractions
(2018-05-01)Low-molecular-weight heparins (LMWHs) are widely used as clinical anticoagulant drugs. LMWHs are heterogeneous and highly negatively charged glycans prepared by chemical or enzymatic depolymerization of unfractionated ... -
Antithrombin III Regulates Complement Activity
(1991)Heparin, a polyion, exerts its main activity to inhibit coagulation through a serine protease inhibitor, antithrombin III. Previous studies have clearly shown that heparin in the absence of antithrombin III also has the ... -
Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats
(2010-03-01)Whole unfractionated heparin can modestly decrease tumor growth, but the dose of heparin is limited by its anticoagulant properties. To overcome this limitation, we modified the chemical structure of heparin and have ... -
Apparent Digestibility of Diet Dominantly Comprised of Phyllostachys Vivax Bamboo Shoots for Captive Giant Pandas
(Pakistan Agricultural Scientists Forum (PAS FORUM), 2015)This study, using the method of direct collection feces, investigated captive giant pandas daily intakes and apparent digestibility coefficients of diet dominantly comprised of Phyllostachys vivax bamboo shoots. The results ... -
Application of Carbon Nanotubes to Wound Healing Biotechnology
(2012-12-07)Carbon nanotubes have remained at the center of nanotechnology research for the past two decades, and have been increasingly present in the areas of biology and biotechnology. While questions still remain about the toxicity ... -
The application of seaweed polysaccharides and their derived products with potential for the treatment of Alzheimer´s disease
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-02-04)Neurodegenerative diseases are among the most widespread diseases affecting humans, and the number of patients is only rising. Seaweed polysaccharide extracts show significant neuroprotective and reparative activities. ... -
Artificial organelles: Digital microfluidic platform for proteoglycan and glycoprotein biosynthesis
(2010-06-01)The development of artificial organelles is a new, fast-growing field in which a variety of techniques have been employed. This article gives a brief overview of the history of artificial organelles, and describes the ... -
Asparagine 405 of heparin lyase II prevents the cleavage of glycosidic linkages proximate to a 3-O-sulfo glucosamine residue
(FEBS Press, 2011)Heparin and heparan sulfate contain a rare 3-O-sulfoglucosamine residue critical for anticoagulation and virus recognition, respectively. The glycosidic linkage proximate to this 3-O-sulfoglucosamine is resistant to cleavage ... -
Assays for determining heparan sulfate and heparin O-sulfotransferase activity and specificity
(Springer, 2014-01-01)O-sulfotransferases (OSTs) are critical enzymes in the cellular biosynthesis of the biologically and pharmacologically important heparan sulfate and heparin. Recently, these enzymes have been cloned and expressed in bacteria ... -
Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis
(2020-08-01)Hyaluronan plays a key role in regulating inflammation and tumor angiogenesis. Of the three transmembrane hyaluronan synthases, HAS2 is the main pro-angiogenic enzyme responsible for excessive hyaluronan production. We ...