Browsing Linhardt Research Labs Papers by Title
Now showing items 767-786 of 1022
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Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two Dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry
(2015-09-01)Low molecular weight heparins (LMWHs) are polydisperse and microheterogenous mixtures of polysaccharides used as anticoagulant drugs. Profiling analysis is important for obtaining deeper insights into the structure of ... -
Profiling pneumococcal type 3-derived oligosaccharides by high resolution liquid chromatography-tandem mass spectrometry
(Elsevier, 2015-06-05)Pneumococcal type-3 polysaccharide (Pn3P) is considered a major target for the development of a human vaccine to protect against Streptococcus pneumoniae infection. Thus, it is critical to develop methods for the preparation ... -
Programming designer DNA nanostructures for inhibition of virus infection
(2022)The challenges underlying current coronavirus disease 2019 treatment and rapid diagnostic development are already well known from previous encounters with newly emerging pathogens (e.g., the 2009 H1N1 pandemic 1,2). ... -
Proline to Arginine Mutations in FGF Receptors 1 and 3 Result in Pfeiffer and Muenke Craniosyntosis Syndromes Through the Enhancement of FGF Binding Affinity
(2004)Identical proline-->arginine gain-of-function mutations in fibroblast growth factor receptor (FGFR) 1 (Pro252Arg), FGFR2 (Pro253Arg) and FGFR3 (Pro250Arg), result in type I Pfeiffer, Apert and Muenke craniosynostosis ... -
Prolonged release and shelf-life of anticoagulant sulfated polysaccharides encapsulated with ZIF-8
(2021-07-31)Natural active polysaccharides are attracting increased attention from pharmaceutical industries for their valuable biological activities. However, the application of polysaccharides has been restricted due to their ... -
Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown
(Nature, 2020-12-01)The thick mucus layer of the gut provides a barrier to infiltration of the underlying epithelia by both the normal microbiota and enteric pathogens. Some members of the microbiota utilise mucin glycoproteins as a nutrient ... -
Properties of Carbohydrates
(2001)The physical, chemical, and biological properties of carbohydrates depend on their primary structures and, less frequently, on their higher-order structures. While monosaccharides are comprised of a single saccharide unit, ... -
Protective effects of six different pectic polysaccharides on DSS-induced IBD in mice
(2022-06-01)Administration of pectic polysaccharides is a therapeutic strategy in the management of gut inflammation. However, the knowledge about the effects of different dietary sources and structure are missing. This study explored ... -
Protein-associated water effects the removal of blood proteins from metallic substrates
(2011-03-01)Removing adsorbed protein from metals has significant health and industrial consequences. There are numerous protein-adsorption studies using model self-assembled monolayers or polymeric substrates but hardly any high-resolution ... -
Proteoglycan Sequence
(Royal Society of Chemistry, 2012)Proteoglycans (PGs) are among the most structurally complex biomacromolecules in nature. They are present in all animal cells and frequently exert their critical biological functions through interactions with protein ligands ... -
Proteoglycans in stem cells
(2012)The remarkable promise of pluripotent and multipotent stem cells (SCs) imparts tremendous optimism for advancement of regenerative medicine, developmental biology, and drug discovery. Perhaps the greatest challenge is to ... -
Proteoglycomics: Recent progress and future challenges
(2010-08-01)Proteoglycomics is a systematic study of structure, expression, and function of proteoglycans, a posttranslationally modified subset of a proteome. Although relying on the established technologies of proteomics and glycomics, ... -
Proteome analysis and selenium-binding peptide identification on proteins sequentially extracted from loach (Misgurnus anguillicaudatus)
(Biochemistry & Physiology, 2017)Loach (Misgurnus anguillicaudatus) is known as a selenium-rich aquatic product. In present study, a sequential extraction method was applied for separation of water, salt and alkali-soluble proteins from loach (Misgurnus ... -
Proteomics of old world camelid (Camelus dromedarius): Better understanding the interplay between homeostasis and desert environment
(Elsevier, 2014)Life is the interplay between structural–functional integrity of biological systems and the influence of the external environment. To understand this interplay, it is useful to examine an animal model that competes with ... -
Purification and Characterization of a Novel Heparinase from Bacteroides stercoris HJ-15
(2000-01-01)A novel type of heparinase (heparin lyase, no EC number) has been purified from Bacteroides stercoris HJ-15, isolated from human intestine, which produces three kinds of heparinases. The enzyme was purified to apparent ... -
Purification and Characterization of Heparan Sulfate Peptidoglycans from Bovine Liver
(Elsevier, 2002)A method for the isolation and purification of peptidoglycan heparan sulfate (HS) from bovine liver is described. Peptidoglycan HS was purified from bovine liver and its structure was characterized. The purity and identity ... -
Purification and Characterization of Heparin Lyases from Flavobacterium heparinum
(Elsevier, 1992)Heparin lyase I has been purified from Flavobacterium heparinum and has been partially characterized (Yang, V. C., Linhardt, R. J., Berstein, H., Cooney, C. L., and Langer, R. (1985) J. Biol. Chem. 260, 1849-1857). There ... -
Purification and Characterization of Heparinase from Flavobacterium heparinum
(Elsevier, 1985)Heparinase (EC 4.2.2.7) isolated from Flavobacterium heparinum was purified to homogeneity by a combination of hydroxylapatite chromatography, repeated gel filtration chromatography, and chromatofocusing. Homogeneity was ... -
Purification and structural elucidation of a water-soluble polysaccharide from the fruiting bodies of the Grifola frondosa
(2018-08-01)Grifola frondosa is a polypore mushroom, which has been used for many centuries by traditional Chinese and Japanese herbalists as a medicinal mushroom. A water-soluble polysaccharide (code as GFP30-2-a, molecular weight: ... -
Purification, Characterization and Specificity of Chondroitin Lyases and Glucuronidase from Flavobacterium heparinum
(1995)The chondroitin lyases from Flavobacterium heparinum (Cytophaga heparinia) have been widely used in depolymerization of glycosaminoglycan and proteoglycan chondroitin sulphates. Oligosaccharide products derived from ...