Browsing Linhardt Research Labs Papers by Title
Now showing items 855-874 of 1022
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Signal Amplification of Target Protein on Heparin Glycan Microarray
(Elsevier, 2008-12-01)A heparin glycan chip (HepGlyChip) with a 4800-fold enhanced signal-to-noise ratio as compared with the control without heparin was developed for high-throughput analysis of heparin-protein interactions for new drug ... -
Significance of 2-O-Sulfonate Group of L-Iduronic Acid Residues in Heparin on the Growth Inhibition of Bovine Pulmonary Artery Smooth Muscle Cells
(Elsevier, 2008)Heparin inhibits the growth of several cell types in vitro, including bovine pulmonary artery smooth muscle cells (BPASMCs). To understand more about the heparin structure required for endogenous activity, chemically ... -
Site-selective reactions for the synthesis of glycoconjugates in polysaccharide vaccine development
(2020-02-15)Carbohydrates are often found linked to lipids or proteins, to form glycoconjugates such as glycolipids, glycoproteins and proteoglycans. These glycoconjugates play important biological roles, involving cell-cell recognition, ... -
Site-specific immobilization of papain on polystyrene beads for the oligo-glutamate synthesis
(2022)In this paper, a reusable heterogeneous catalyst of papain was prepared and used to catalyze the polymerization for oligo-glutamate. In silico, the 9,9-bis(2,3-epoxypropyl) fluorenyl group (DDI) carried on polystyrene beads ... -
Small Heparin Fragments Regulate the Amplification Pathway of Complement
(1985-01-01)Heparin is a highly sulfated, polydisperse and heterogenepus glycosaminoglycan which has been well characterized for its ability to regulate multiple sites in the complement cascade. Although previous studies demonstrated ... -
Solid-Phase Chemoenzymatic Synthesis of Neuraminic Acid Based C-glycosides
(American Chemical Society (ACS), 2004)The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries ... -
Soluble klotho and heparin modulate the pathologic cardiac actions of FGF23 in chronic kidney disease
(Elsevier, 2022)Fibroblast growth factor (FGF) 23 is a phosphate-regulating hormone that is elevated in patients with chronic kidney disease and associated with cardiovascular mortality. Experimental studies showed that elevated FGF23 ... -
Solution Structures of Chemoenzymatically Synthesized Heparin and its Precursors
(American Chemical Society (ACS), 2008-10-01)We report the first chemoenzymatic synthesis of the stable isotope-enriched heparin from a uniformly labeled [(13)C,(15)N]N-acetylheparosan (-GlcA(1,4)GlcNAc-) prepared from E. coli K5. Glycosaminoglycan (GAG) precursors ... -
Solvolytic depolymerization of chondroitin and dermatan sulfates
(2009-05-12)It is essential to establish a library of glycosaminoglycan oligosaccharides from the chondroitin and dermatan sulfates to investigate their biological functions and structure-activity relationships (SARs). There are several ... -
Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system
(2016-08-01)Oxidized starch, one of the most important starch derivatives, has many different properties and applications. Currently, there are two ways to produce oxidized starch, through specific and nonspecific oxidation. Specific ... -
Specificity and action pattern of heparanase Bp, a β-glucuronidase from Burkholderia pseudomallei
(2019-08-01)The specificity and action pattern of a β-glucuronidase derived from the pathogenic bacteria Burkholderia pseudomallei and expressed in Escherichia coli as a recombinant protein has been evaluated. While this enzyme shows ... -
Specificity Studies on the Heparin Lyases from Flavobacterium heparinum
(1993-01-01)An understanding of the substrate specificity study of the heparin lyases (heparinase and heparitinases) is crucial for elucidation of the sequence of heparin and heparan sulfate. Four chemically modified heparins have ... -
SPR Biosensor Probing the Interactions between TIMP-3 and Heparin/GAGs
(Multidisciplinary Digital Publishing Institute (MDPI), 2015-01-01)Tissue inhibitor of metalloproteinases-3 (TIMP-3) belongs to a family of proteins that regulate the activity of matrix metalloproteinases (MMPs), which can process various bioactive molecules such as cell surface receptors, ... -
Stabilizing leaf and branch compost cutinase (LCC) withglycosylation: Mechanism and effect on PET hydrolysis
(2018)Cutinases are polyester hydrolases that show a remarkable capability to hydrolyze polyethylene terephthalate (PET) to its monomeric units. This revelation has stimulated research aimed at developing sustainable and green ... -
Stable-isotopic analysis of porcine, bovine, and ovine heparins
(Elsevier, 2015-01-01)The assessment of provenance of heparin is becoming a major concern for the pharmaceutical industry and its regulatory bodies. Batch-specific [carbon (δ13C), nitrogen (δ15N), oxygen (δ18O), sulfur (δ34S), and hydrogen (δD)] ... -
Stereoselective Synthesis of a C-linked Neuraminic Acid Disaccharide: Potential Building Block for the Synthesis of C-Analogs of Polysialic Acids
(American Chemical Society (ACS), 2008-12-05)C-Linked neuraminic acid disaccharide was synthesized in a diastereoselective manner from a sulfone donor and aldehyde acceptor, which was protected as propargyl ether, through a samarium mediated coupling reaction. The ... -
Stereoselective Synthesis of Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B) from D-Xylose
(American Chemical Society (ACS), 2006)The first naturally occurring anhydrophytosphingosine, pachastrissamine (jaspine B), a marine compound cytotoxic toward P388, A549, HT29, and MEL28 cell lines at IC(50) = 0.01 microg/mL level, has been stereoselectively ... -
Stereoselective Total Synthesis of (-)-Cleistenolide
(American Chemical Society (ACS), 2010)A facile stereoselective total synthesis of cleistenolide (1) from the natural chiral template d-arabinose has been achieved in eight steps and 49% overall yield, employing key steps including Wittig olefination, selective ... -
Storage stability studies on interesterified blend-based fast-frozen special fats for oxidative stability, crystallization characteristics and physical properties
(2020-02-15)The storage stability of two kinds of interesterified blend-based fast-frozen special fats (PS:SO-IBSF, PS:RO-IBSF) with varied triacylglycerols (TAGs) compositions under different temperatures for 4 weeks was investigated. ... -
Strategy for the Sequence Analysis of Heparin
(1995-01-01)The versatile biological activities of proteoglycans are mainly mediated by their glycosaminoglycan (GAG) components. Unlike proteins and nucleic acids, no satisfactory method for sequencing GAGs has been developed. This ...