Browsing Linhardt Research Labs Papers by Title
Now showing items 61-80 of 1022
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Analysis of heparins derived from bovine tissues and comparison to porcine intestinal heparins
(2016-09-01)Heparin is a widely used clinical anticoagulant. It is also a linear glycosaminoglycan with an average mass between 10 and 20 kDa and is primarily made up of trisulfated disaccharides comprised of 1,4-linked iduronic acid ... -
Analysis of pharmaceutical heparins and potential contaminants using 1H-NMR and PAGE
(2009-01-01)In 2008, heparin (active pharmaceutical ingredient, API) lots were associated with anaphylactoid-type reactions. Oversulfated chondroitin sulfate (OSCS), a semi-synthetic glycosaminoglycan (GAG), was identified as a ... -
Analysis of the Biochemical Mechanisms for the Endocrine Actions of FGF23
(Oxford, 2005)Fibroblast growth factor (FGF)-23 has emerged as an endocrine regulator of phosphate and of vitamin D metabolism. It is produced in bone and, unlike other FGFs, circulates in the bloodstream to ultimately regulate phosphate ... -
Analysis of the glycosaminoglycan chains of proteoglycans
(Sage, 2021-02-01)Glycosaminoglycans (GAGs) are heterogeneous, negatively charged, macromolecules that are found in animal tissues. Based on the form of component sugar, GAGs have been categorized into four different families: heparin/heparan ... -
Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using Surface Plasmon Resonance
(American Chemical Society (ACS), 2012-08-28)Heparin and related heparan sulfate interact with a number of cytokines and growth factors, thereby playing an essential role in many physiological and pathophysiological processes by involving both signal transduction and ... -
Analysis of the Structure of Heparin and Heparan Sulfate by HighResolution Separation of Oligosaccharides
(1997)Heparin and heparan sulfate are mixtures of highly sulfated linear polysaccharides having a molecular weight (MW) ranging from 5000 to 40,000 with an MW avg of 10,000 to 25,000 (1). They are members of a family of molecules ... -
Analysis of total human urinary glycosaminoglycan disaccharides by liquid chromatography-tandem mass spectrometry
(2015-06-16)The determination of complex analytes, present at low concentrations, in biological fluids poses a difficult challenge. This study relies on an optimized method of recovery, enzymatic treatment, and disaccharide analysis ... -
Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone
(1983-01-01)Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant ... -
Annexin V-Heparin Oligosaccharide Complex Suggests Heparan Sulfate-Mediated Assembly on Cell Surfaces
(2001-01-01)Background: Annexin V, an abundant anticoagulant protein, has been proposed to exert its effects by self-assembling into highly ordered arrays on phospholipid membranes to form a protective anti-thrombotic shield at the ... -
Anti-inflammation effects of highly purified low-Mw RG-I pectins on LPS-activated macrophages
(2021-11-01)Pectic oligosaccharides are viewed as excellent immunomodulator, but the specific molecular weight (Mw) range required for anti-inflammatory effects remains unclear. In this study, citrus pectins was depolymerized by the ... -
Anti-metastatic effect of non-anticoagulant low molecular weight heparin versus standard low molecular weight heparin, enoxaparain
(Thieme Medical Publishers, 2006)Low-molecular-weight heparins (LMWH) exhibit potent anticoagulant efficacy via their plasmatic effects on thrombin and factor Xa. These agents are also effective in releasing endothelial tissue factor pathway inhibitor ... -
Anti-proliferative effects of O-acyl-low-molecular-weight heparin derivatives on bovine pulmonary artery smooth muscle cells
(Springer, 2011-08-01)Heparin (HP) inhibits the growth of several cell types in vitro including bovine pulmonary artery (BPA) smooth muscle cells (SMCs). In initial studies we discovered that an O-hexanoylated low-molecular-weight (LMW) HP ... -
Anti-SARS-CoV-2 activity of rhamnan sulfate from Monostroma nitidum
(Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)The COVID-19 pandemic is a major human health concern. The pathogen responsible for COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), invades its host through the interaction of its spike (S) protein ... -
Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88
(2001)Heparinomimetic mannopentaose phosphate sulfate (PI-88) (Progen Industries Ltd. Brisbane, Australia), currently developed as an anticoagulant and antiproliferative agent, mainly is composed of a pentomannan. However, ... -
Antimicrobial effects of positively charged, conductive electrospun polymer fibers
(Elsevier, 2020-11-01)In recent years, electrospun polymer fibers have gained attention for various antibacterial applications. In this work, the effect of positively charged polymer fiber mats as antibacterial gauze is studied using electrospun ... -
Antimicrobial mechanism of resveratrol-trans-dihydrodimer produced from peroxidase-mediated oligomerization of resveratrol
(2015)Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of ... -
Antiseptic single wall carbon nanotube bandages
(2009-05-01)Single wall carbon nanotubes (SWCNTs) are coated with polyvinylpyrrolidone-iodine (povidone-iodine or PVPI) in water. This solution of SWCNT and PVPI is deposited as a composite film, composed of individual and bundled ... -
Antithrombin III Binding Site Analysis of Low Molecular Weight Heparin Fractions
(2018-05-01)Low-molecular-weight heparins (LMWHs) are widely used as clinical anticoagulant drugs. LMWHs are heterogeneous and highly negatively charged glycans prepared by chemical or enzymatic depolymerization of unfractionated ... -
Antithrombin III Regulates Complement Activity
(1991)Heparin, a polyion, exerts its main activity to inhibit coagulation through a serine protease inhibitor, antithrombin III. Previous studies have clearly shown that heparin in the absence of antithrombin III also has the ... -
Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats
(2010-03-01)Whole unfractionated heparin can modestly decrease tumor growth, but the dose of heparin is limited by its anticoagulant properties. To overcome this limitation, we modified the chemical structure of heparin and have ...